Diseases of the Pharynx — MCQs
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Paterson-Kelly syndrome is characterized by all of the following except?
A 70-year-old male presents with hearing loss and tinnitus. On examination, he has a conductive type of deafness and a dull tympanic membrane on the right side. Lymph nodal enlargement of 3x3 cm was noted in the posterior triangle of the neck. Tympanogram revealed a type B wave. What is the most likely diagnosis?
Eustachian tube opens due to contraction of which of the following muscles?
What is the most common presentation of nasopharyngeal carcinoma?
Which instrument is used to visualize the nasopharynx in an outpatient department setting?
Web constriction is seen in which part of the esophagus in Plummer-Vinson syndrome?
The bed of the tonsil is formed by which muscle?
Which of the following is NOT a differential diagnosis for a grey-white membrane on the tonsil?
A 45-year-old patient complains of pain in the throat, which is aggravated on swallowing and radiates to the ear and the posterior part of the tongue. What is the likely diagnosis?
Which of the following structures does not form Waldeyer's ring?
Diseases of the Pharynx Indian Medical PG Practice Questions and MCQs
Question 221: Paterson-Kelly syndrome is characterized by all of the following except?
- A. Premalignant potential
- B. Lower esophageal web (Correct Answer)
- C. Iron deficiency anemia
- D. Common in females
Explanation: **Explanation:** Paterson-Kelly syndrome (also known as **Plummer-Vinson syndrome**) is a clinical triad characterized by iron deficiency anemia, glossitis, and esophageal webs. **Why Option B is the correct answer:** The characteristic esophageal web in Paterson-Kelly syndrome is located in the **post-cricoid region (upper esophagus)**, not the lower esophagus. Lower esophageal webs (Schatzki rings) are distinct clinical entities often associated with hiatal hernia and reflux, rather than iron deficiency. **Analysis of other options:** * **Option A (Premalignant potential):** It is considered a premalignant condition. Long-standing mucosal atrophy increases the risk of developing **post-cricoid carcinoma** (Squamous Cell Carcinoma). * **Option C (Iron deficiency anemia):** This is a hallmark feature. The anemia leads to mucosal atrophy, which is thought to contribute to web formation. Patients often present with spoon-shaped nails (koilonychia). * **Option D (Common in females):** The syndrome shows a strong female predilection, typically affecting middle-aged women (4th to 7th decades). **High-Yield Clinical Pearls for NEET-PG:** * **Triad:** Iron deficiency anemia + Dysphagia + Upper esophageal web. * **Site of Web:** Post-cricoid region (Cricopharyngeal level). * **Diagnosis:** Best visualized via **Barium Swallow** (lateral view), appearing as a thin, horizontal filling defect. * **Treatment:** Iron supplementation often improves symptoms; persistent webs may require endoscopic dilatation. * **Associated Findings:** Glossitis (smooth tongue), angular cheilitis, and achlorhydria.
Question 222: A 70-year-old male presents with hearing loss and tinnitus. On examination, he has a conductive type of deafness and a dull tympanic membrane on the right side. Lymph nodal enlargement of 3x3 cm was noted in the posterior triangle of the neck. Tympanogram revealed a type B wave. What is the most likely diagnosis?
- A. Middle ear tumor
- B. Nasopharyngeal malignancy (Correct Answer)
- C. Acoustic neuroma
- D. Tuberculosis of middle ear
Explanation: ### Explanation The clinical presentation of a **70-year-old male** with unilateral conductive hearing loss, a dull tympanic membrane, and a Type B tympanogram indicates **Otitis Media with Effusion (OME)**. In an elderly patient, unilateral OME is **Nasopharyngeal Carcinoma (NPC)** until proven otherwise. **Why Nasopharyngeal Malignancy is correct:** NPC typically originates in the **Fossa of Rosenmüller**. As the tumor grows, it obstructs the opening of the **Eustachian tube**, leading to negative middle ear pressure and subsequent fluid accumulation (serous otitis media). This results in conductive hearing loss and a **Type B (flat) tympanogram**. The presence of a 3x3 cm mass in the **posterior triangle (Level V lymph nodes)** is a classic sign, as NPC frequently presents with early lymphatic spread. **Why other options are incorrect:** * **Middle ear tumor:** While it can cause conductive loss, it rarely presents with isolated posterior triangle lymphadenopathy. * **Acoustic neuroma:** This is a tumor of the 8th cranial nerve presenting with **sensory-neural hearing loss (SNHL)** and a Type A tympanogram. * **Tuberculosis of middle ear:** Usually presents with painless otorrhoea, multiple perforations of the tympanic membrane, and pale granulations, rather than a dull, intact membrane with a Type B curve. **NEET-PG High-Yield Pearls:** * **Trotter’s Triad (for NPC):** 1. Conductive hearing loss (Eustachian tube blockage), 2. Ipsilateral facial pain/numbness (CN V involvement), 3. Palatal paralysis (CN X involvement). * **Most common site:** Fossa of Rosenmüller. * **Risk Factor:** Strong association with **Epstein-Barr Virus (EBV)**. * **Rule of Thumb:** Any adult with unilateral serous otitis media must undergo fiberoptic nasopharyngoscopy to rule out malignancy.
Question 223: Eustachian tube opens due to contraction of which of the following muscles?
- A. Buccinator
- B. Levator palati (Correct Answer)
- C. Stylohyoid
- D. Stylopharyngeus
Explanation: **Explanation:** The Eustachian tube (ET) is normally closed at its pharyngeal end to protect the middle ear from nasopharyngeal pressure changes and secretions. It opens during swallowing, yawning, or sneezing to equalize middle ear pressure. **1. Why Levator Palati is correct:** The opening of the Eustachian tube is primarily a muscular phenomenon. While the **Tensor veli palatini** is considered the "main" dilator of the tube (often called the *dilator tubae*), the **Levator veli palatini** plays a crucial synergistic role. When it contracts, it increases the vertical dimension of the soft palate and helps elevate the floor of the tube, facilitating its opening. In many standardized exams like NEET-PG, if Tensor veli palatini is absent from the options, Levator palati is the most appropriate choice. **2. Why other options are incorrect:** * **Buccinator:** A muscle of facial expression (buccal branch of CN VII) that compresses the cheeks; it has no anatomical relation to the ET. * **Stylohyoid:** A muscle of the neck that elevates the hyoid bone during swallowing; it does not act on the pharyngeal opening of the ET. * **Stylopharyngeus:** A longitudinal muscle of the pharynx (innervated by CN IX) that elevates the larynx and pharynx; while it is involved in swallowing, it does not directly open the ET. **Clinical Pearls for NEET-PG:** * **Primary Dilator:** Tensor Veli Palatini (Innervated by the Nerve to Medial Pterygoid, a branch of **V3**). * **Secondary Dilator:** Levator Veli Palatini (Innervated by the Pharyngeal Plexus, primarily **CN X**). * **Ostmann’s Fat Pad:** Located in the lateral wall of the ET; its loss (e.g., in rapid weight loss) leads to a **Patulous Eustachian Tube**. * **Anatomy:** The ET is 36mm long; the lateral 1/3 is bony, and the medial 2/3 is cartilaginous. In infants, the tube is shorter, wider, and more horizontal, predisposing them to Otitis Media.
Question 224: What is the most common presentation of nasopharyngeal carcinoma?
- A. Epistaxis
- B. Cervical lymphadenopathy (Correct Answer)
- C. Nasal obstruction
- D. Hearing loss
Explanation: **Explanation:** Nasopharyngeal Carcinoma (NPC) is a unique malignancy often associated with the Epstein-Barr Virus (EBV). The most common presenting symptom, seen in approximately **60-80% of cases**, is **painless cervical lymphadenopathy**. **Why Cervical Lymphadenopathy is the Correct Answer:** The nasopharynx has an extremely rich lymphatic network. Tumors in this region frequently remain clinically silent while metastasizing early to the cervical nodes. The most common site for involvement is the **upper deep cervical nodes** (specifically the **Node of Rouviere** or the Jugulodigastric nodes). Often, a lump in the neck is the first and only sign that brings the patient to the clinic. **Analysis of Incorrect Options:** * **A. Epistaxis:** While blood-stained nasal discharge or post-nasal drip can occur, frank epistaxis is less common than nodal involvement. * **C. Nasal Obstruction:** This occurs as the tumor grows to fill the nasopharyngeal space, but it is typically a later feature compared to lymphatic spread. * **D. Hearing Loss:** NPC can block the Eustachian tube orifice, leading to **Unilateral Serous Otitis Media**. While this is a classic diagnostic sign (Trotter’s Triad), it is not the *most common* initial presentation. **High-Yield Clinical Pearls for NEET-PG:** * **Trotter’s Triad:** 1. Conductive hearing loss (Eustachian tube blockage), 2. Ipsilateral soft palate paralysis (CN X involvement), 3. Trigeminal neuralgia (CN V involvement). * **Fossa of Rosenmüller:** The most common site of origin for NPC. * **Treatment of Choice:** Radiotherapy is the primary treatment (NPC is highly radiosensitive). * **Diagnostic Marker:** Elevated titers of **IgA antibodies against EBV VCA** (Viral Capsid Antigen).
Question 225: Which instrument is used to visualize the nasopharynx in an outpatient department setting?
- A. PNS mirror
- B. Tongue depressor
- C. Both PNS mirror and tongue depressor (Correct Answer)
- D. None of the above
Explanation: To visualize the nasopharynx in an outpatient department (OPD) setting, a procedure called **Posterior Rhinoscopy (PR)** is performed. This procedure requires the simultaneous use of both the **PNS (Post-nasal Space) mirror** and a **tongue depressor**. ### **Why Option C is Correct** The nasopharynx is located behind the nasal cavity and above the soft palate, making it impossible to see directly through the mouth. 1. **Tongue Depressor:** This is used to depress the anterior two-thirds of the tongue, creating space in the oropharynx. 2. **PNS Mirror (St. Clair Thompson’s Mirror):** This is a small, angled mirror that is warmed (to prevent fogging) and introduced behind the soft palate without touching the posterior pharyngeal wall (to avoid the gag reflex). The light is reflected off the mirror into the nasopharynx, and the image of the structures (like the choanae, Eustachian tube orifices, and adenoids) is reflected back to the examiner. Therefore, both instruments are indispensable for a successful examination. ### **Why Other Options are Incorrect** * **Option A & B:** While both are used, selecting one over the other is incomplete. A PNS mirror cannot be positioned correctly if the tongue obstructs the view, and a tongue depressor alone only allows visualization of the oropharynx. ### **High-Yield Clinical Pearls for NEET-PG** * **Structures seen on PR:** Posterior border of the nasal septum (vomer), choanae, posterior ends of turbinates, Eustachian tube opening, Rosenmüller’s fossa (common site for Nasopharyngeal Carcinoma), and the adenoid pad. * **Gold Standard:** While PR is a classic bedside skill, **Fiberoptic Nasopharyngoscopy** is now the gold standard for detailed visualization in modern practice. * **Positioning:** The patient should be sitting with the mouth wide open and breathing through the mouth to relax the soft palate.
Question 226: Web constriction is seen in which part of the esophagus in Plummer-Vinson syndrome?
- A. Thoracic
- B. Abdominal
- C. Cervical (Correct Answer)
- D. Any of the above
Explanation: **Explanation:** **Plummer-Vinson Syndrome (PVS)**, also known as Paterson-Brown-Kelly syndrome, is characterized by the classic triad of **iron-deficiency anemia, dysphagia, and esophageal webs.** **Why Cervical is correct:** The esophageal web in PVS is a thin, mucosal fold that typically occurs in the **post-cricoid region**, which is located in the **cervical esophagus**. These webs are eccentric, semi-lunar, and composed of squamous epithelium. They occur at the junction of the hypopharynx and the esophagus, making the cervical region the definitive site of constriction. **Why other options are incorrect:** * **Thoracic Esophagus:** While webs can rarely occur here (e.g., in cases of Gastroesophageal Reflux), they are not characteristic of PVS. The thoracic part is more commonly associated with Schatzki rings (at the squamocolumnar junction). * **Abdominal Esophagus:** This is the shortest segment, located below the diaphragm. Constrictions here are usually due to hiatal hernias or peptic strictures, not PVS webs. **High-Yield Clinical Pearls for NEET-PG:** * **Demographics:** Most common in middle-aged females. * **Clinical Features:** Glossitis (smooth tongue), koilonychia (spoon-shaped nails), and angular stomatitis. * **Malignant Potential:** PVS is considered a **precancerous condition**. It significantly increases the risk of **Squamous Cell Carcinoma** of the post-cricoid region and upper esophagus. * **Diagnosis:** Best visualized via **Barium Swallow** (lateral view) showing a "shelf-like" projection. * **Treatment:** Iron supplementation often resolves the dysphagia; however, severe webs may require endoscopic dilation.
Question 227: The bed of the tonsil is formed by which muscle?
- A. Superior constrictor (Correct Answer)
- B. Middle constrictor
- C. Inferior constrictor
- D. Platysma
Explanation: **Explanation:** The **palatine tonsil** is located in the tonsillar sinus (fossa) between the palatoglossal and palatopharyngeal arches. The **tonsillar bed** refers to the structures lying lateral to the tonsillar capsule. 1. **Why Superior Constrictor is Correct:** The bed of the tonsil is primarily formed by the **superior constrictor muscle** and the **styloglossus muscle**. These muscles separate the tonsil from the parapharyngeal space. The superior constrictor forms the muscular floor of the fossa, and its deficiency superiorly is filled by the pharyngobasilar fascia. 2. **Why Other Options are Incorrect:** * **Middle and Inferior Constrictors:** These are located lower in the pharynx. The middle constrictor originates near the hyoid bone, and the inferior constrictor forms the lower pharynx/upper esophagus junction. They do not contribute to the tonsillar fossa. * **Platysma:** This is a superficial muscle of the neck located within the subcutaneous tissue. It is far more lateral and superficial than the pharyngeal wall. **High-Yield Clinical Pearls for NEET-PG:** * **Structures in the Tonsillar Bed (Medial to Lateral):** Pharyngobasilar fascia → Superior constrictor/Styloglossus muscles → Buccopharyngeal fascia → Parapharyngeal space. * **Glossopharyngeal Nerve (CN IX):** This nerve lies in the tonsillar bed, just lateral to the superior constrictor. Injury during tonsillectomy can lead to referred ear pain or loss of taste on the posterior 1/3 of the tongue. * **Vascularity:** The **facial artery** (via the tonsillar branch) is the main arterial supply. The **external palatine vein** (paratonsillar vein) is the most common cause of primary hemorrhage during tonsillectomy. * **Internal Carotid Artery:** Lies approximately 2.5 cm posterolateral to the tonsil and is generally safe during routine surgery unless tortuous.
Question 228: Which of the following is NOT a differential diagnosis for a grey-white membrane on the tonsil?
- A. Candidiasis
- B. Ludwig's Angina (Correct Answer)
- C. Vincent's Angina
- D. Malignancy of the tonsil
Explanation: **Explanation:** The presence of a **grey-white membrane** on the tonsil is a classic clinical sign that necessitates differentiating between infectious, inflammatory, and neoplastic conditions. **Why Ludwig’s Angina is the correct answer:** Ludwig’s Angina is a **submandibular space infection** (cellulitis), typically odontogenic in origin. It involves the submental, sublingual, and submandibular spaces bilaterally. Clinically, it presents with "woody" hard swelling of the neck, brawny edema, and elevation of the floor of the mouth/tongue. It does **not** involve the tonsillar mucosa or produce a membrane; therefore, it is not a differential diagnosis for a tonsillar membrane. **Analysis of Incorrect Options:** * **Candidiasis (Moniliasis):** Presents as creamy white, curd-like patches on the tonsils and oral mucosa. When scraped, it may leave an erythematous, bleeding base. * **Vincent’s Angina:** An infection caused by *Borrelia vincentii* and *Fusobacterium*. It typically presents as a unilateral ulcer covered by a dirty greyish-white slough/membrane. * **Malignancy of the Tonsil:** Squamous cell carcinoma or lymphoma can present as an ulcerative lesion with a necrotic slough or "membrane" covering the growth, often associated with fetid breath and cervical lymphadenopathy. **High-Yield Clinical Pearls for NEET-PG:** * **Diphtheria:** The most classic cause of a "true" greyish-white membrane that is tough, adherent, and bleeds on removal. * **Infectious Mononucleosis (EBV):** Presents with a thick exudative membrane, generalized lymphadenopathy, and a positive Paul-Bunnell test. * **Agranulocytosis:** Can cause necrotic tonsillar ulcers with a greyish membrane due to lack of neutrophils. * **Aphthous Ulcers:** Can occur on the tonsil, appearing as a pale yellow membrane with a red halo.
Question 229: A 45-year-old patient complains of pain in the throat, which is aggravated on swallowing and radiates to the ear and the posterior part of the tongue. What is the likely diagnosis?
- A. Sluder's neuralgia
- B. Glossopharyngeal neuralgia (Correct Answer)
- C. Disorder of the temporomandibular joint
- D. Trigeminal neuralgia
Explanation: ### Explanation **Glossopharyngeal Neuralgia (GPN)** is the correct diagnosis based on the classic distribution of pain. The glossopharyngeal nerve (CN IX) provides sensory innervation to the posterior third of the tongue, the tonsillar fossa, and the oropharynx. It also gives off the **Jacobson’s nerve** (tympanic branch), which supplies the middle ear. The hallmark of GPN is paroxysmal, lancinating pain triggered by actions like **swallowing, talking, or coughing**. The pain typically radiates from the throat/tonsillar pillar to the **ear** (referred otalgia via Jacobson’s nerve) and the **base of the tongue**. #### Why the other options are incorrect: * **Sluder’s Neuralgia (Sphenopalatine Ganglion Neuralgia):** Characterized by pain centered around the orbit, nose, and maxilla, often associated with nasal congestion or rhinorrhea. It does not typically involve the tongue or throat triggered by swallowing. * **Disorder of the TMJ (Costen’s Syndrome):** Pain is localized to the preauricular region and jaw, usually aggravated by chewing or opening the mouth wide, rather than swallowing. * **Trigeminal Neuralgia:** The most common facial neuralgia, involving the V2 or V3 branches. Pain is felt in the cheek, jaw, or teeth. While V3 can cause tongue pain, it does not involve the deep oropharynx or trigger upon swallowing. #### NEET-PG High-Yield Pearls: * **Eagle’s Syndrome:** A key differential diagnosis where an elongated styloid process irritates the glossopharyngeal nerve, causing similar symptoms. * **Treatment:** Medical management starts with **Carbamazepine** (first-line). Surgical options include Microvascular Decompression (MVD) or rhizotomy. * **Vagal involvement:** In rare cases, GPN can be associated with syncope or bradycardia due to the proximity of the glossopharyngeal nerve to the vagus nerve.
Question 230: Which of the following structures does not form Waldeyer's ring?
- A. Palatine tonsils
- B. Adenoids
- C. Jugulodigastric node (Correct Answer)
- D. Lateral pharyngeal bands
Explanation: ### Explanation **Waldeyer’s Ring** is a circular arrangement of lymphoid tissue located in the pharynx at the entrance of the aerodigestive tract. It serves as the first line of defense against inhaled or ingested pathogens. **Why Option C is correct:** The **Jugulodigastric node** (also known as the "tonsillar node") is a deep cervical lymph node. While it is the primary site for lymphatic drainage from the palatine tonsils, it is an **extrapharyngeal** structure. Waldeyer’s ring consists exclusively of **subepithelial lymphoid tissue** located within the pharyngeal wall, not the lymph nodes themselves. **Why the other options are incorrect:** Waldeyer’s ring is composed of the following four main components: * **Adenoids (Nasopharyngeal tonsil):** Located in the roof and posterior wall of the nasopharynx (Option B). * **Palatine tonsils:** Located in the oropharynx between the palatoglossal and palatopharyngeal arches (Option A). * **Lingual tonsils:** Located on the posterior one-third of the tongue. * **Tubal tonsils:** Located in the Fossa of Rosenmüller, near the opening of the Eustachian tube. * **Lateral pharyngeal bands** and discrete lymphoid follicles on the posterior pharyngeal wall also contribute to the ring (Option D). **High-Yield Clinical Pearls for NEET-PG:** 1. **Passavant’s Ridge:** Formed by the contraction of the palatopharyngeus muscle; it is not part of the ring but is a key landmark in the oropharynx. 2. **Lymphatic Drainage:** Unlike lymph nodes, the components of Waldeyer’s ring **do not possess afferent lymphatics**; they only have efferent drainage. 3. **Infection:** Chronic inflammation of the lateral pharyngeal bands is often seen in patients post-tonsillectomy (compensatory hypertrophy).
Practice by Chapter
Pharyngitis
Practice Questions
Tonsillitis
Practice Questions
Peritonsillar Abscess
Practice Questions
Retropharyngeal Abscess
Practice Questions
Adenoid Hypertrophy
Practice Questions
Sleep-Disordered Breathing
Practice Questions
Obstructive Sleep Apnea
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Nasopharyngeal Carcinoma
Practice Questions
Oropharyngeal Carcinoma
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Hypopharyngeal Carcinoma
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Dysphagia
Practice Questions
Globus Pharyngeus
Practice Questions
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