Corneal Transparency is maintained by which of the following GAGs?

Keratan Sulphate. ***Keratan Sulphate*** - **Keratan sulfate** is a major glycosaminoglycan (GAG) found in the **cornea**, where its specific highly hydrated structure and arrangement help maintain corneal transparency. - The uniform spacing of collagen fibrils, maintained by keratan sulfate, is crucial for minimizing light scattering and allowing light to pass through the cornea. *Dermatan Sulphate* - **Dermatan sulfate** is primarily found in **skin, blood vessels, and heart valves**, contributing to tissue strength and elasticity. - It plays a significant role in wound healing and cardiovascular function, but not directly in maintaining corneal transparency. *Heparan Sulphate* - **Heparan sulfate** is ubiquitously found on **cell surfaces and in the extracellular matrix**, particularly in the basement membranes. - It is involved in cell adhesion, growth factor binding, and anticoagulant activity, but is not the primary GAG responsible for corneal transparency. *Chondroitin Sulphate* - **Chondroitin sulfate** is abundant in **cartilage, bone, and connective tissues**, providing compressive strength and elasticity. - While present in some ocular tissues, it is not the dominant GAG responsible for the unique transparent properties of the cornea. [Practice more Biochemistry PYQs on OnCourse]

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NEET-PG 2021 — Biochemistry

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