NEET-PG 2012 - Obstetrics and Gynecology PYQs Practice Questions

Q: The thickness of the endometrium at the time of implantation is:

7 - 10 mm. ***7 - 10 mm*** - At the time of **implantation** (day 6-10 post-fertilization, around day 20-24 of the menstrual cycle), the endometrium is in the **mid-secretory phase** and measures **7-10 mm** in thickness. - This is the **optimal thickness** for successful embryo implantation, characterized by a receptive endometrium with **decidualization**, **spiral artery development**, and **glycogen-rich glandular secretions**. - Endometrial thickness <7 mm is associated with **poor implantation rates** and reduced pregnancy success. *3 - 4 mm* - An endometrial thickness of 3-4 mm is **too thin** for successful implantation. - This thickness is typically seen in the **early proliferative phase** (immediately after menstruation), not during the implantation window. - Thin endometrium (<7 mm) is associated with **poor receptivity** and lower pregnancy rates in both natural conception and assisted reproduction. *20 - 30 mm* - An endometrial thickness of 20-30 mm is **abnormally thick** and not conducive to normal implantation. - Such thickness may indicate **endometrial hyperplasia**, **polyps**, or other pathological conditions requiring investigation. *30 - 40 mm* - An endometrial thickness of 30-40 mm is **severely abnormal** and would likely prevent successful implantation. - This extreme thickness suggests significant pathology such as **endometrial hyperplasia** or **malignancy** and requires urgent evaluation. [Practice more Obstetrics and Gynecology PYQs on OnCourse]

Q: What is the most common primary malignancy of the fallopian tube?

Serous carcinoma. ***Serous carcinoma*** - **Serous carcinoma** is the most common type of **primary** fallopian tube malignancy, accounting for approximately **90%** of primary tumors. - It often shares molecular and morphological similarities with **high-grade serous ovarian carcinoma** and **primary peritoneal cancer**. - Note: While primary fallopian tube cancer is rare (0.14-1.8% of gynecologic malignancies), metastatic disease to the fallopian tube is more common, typically from **ovarian or endometrial** primaries. *Squamous cell carcinoma* - **Squamous cell carcinoma** is exceedingly rare in the fallopian tube, as the tubal lining is composed of **ciliated and secretory columnar epithelium**, not squamous epithelium. - When present, it usually represents **metastatic spread** from cervical or other primary sites. *Teratoma* - **Teratomas** are germ cell tumors typically found in the **ovaries**, composed of tissues from multiple germ layers. - Primary teratomas of the fallopian tube are **extraordinarily rare** and not the most common primary malignancy. *Choriocarcinoma* - **Choriocarcinoma** is a highly malignant **gestational trophoblastic neoplasm** usually associated with pregnancy complications. - It primarily occurs in the **uterus**, and primary fallopian tube choriocarcinoma is **exceptionally uncommon**. [Practice more Obstetrics and Gynecology PYQs on OnCourse]

Q: Which of the following is the MOST CRITICAL indication for Acyclovir use during pregnancy?

Treatment of disseminated herpes. ***Treatment of disseminated herpes*** - **Disseminated herpes** in pregnancy is a severe, life-threatening condition for both the mother and the fetus, making acyclovir use critically indicated. - This systemic infection can lead to **visceral organ involvement**, **encephalitis**, and significantly increased maternal and fetal morbidity and mortality. - Immediate treatment with intravenous acyclovir is essential to prevent **multi-organ failure** and death. *Treatment of chickenpox in the first trimester* - While chickenpox in the first trimester can be serious, leading to **congenital varicella syndrome**, acyclovir's role here is primarily to mitigate maternal illness, not as critical as disseminated herpes. - The risk of congenital varicella syndrome for the fetus is relatively low (around 0.4%) after maternal infection in the first trimester. *Prophylaxis for recurrent herpes during pregnancy* - **Prophylactic acyclovir** in the third trimester is commonly used to prevent recurrent genital herpes and reduce the risk of **neonatal herpes**, but it is not as acutely critical as treating disseminated disease. - This intervention aims to prevent transmission during delivery rather than managing an immediate, life-threatening maternal or fetal condition. *Prevention of cytomegalovirus infection in pregnancy* - Acyclovir has **minimal activity against CMV** and is not indicated for CMV prevention or treatment. - **Ganciclovir** or **valganciclovir** are the antivirals used for CMV, not acyclovir. [Practice more Obstetrics and Gynecology PYQs on OnCourse]

Q: Which of the following is not a recognized risk factor for endometrial carcinoma?

Smoking. ***Smoking*** - Smoking is generally not considered a risk factor for endometrial carcinoma; in fact, some studies suggest it may paradoxically **decrease risk** by altering estrogen metabolism. - While smoking is a known risk factor for many cancers, its effect on **estrogen-dependent cancers** like endometrial cancer is complex and often opposite to that of other cancers. *Obesity* - Obesity is a significant risk factor due to the increased peripheral conversion of **androgens to estrogens** in adipose tissue, leading to unopposed estrogen stimulation of the endometrium. - This **elevated estrogen exposure** promotes endometrial hyperplasia and increases the risk of malignant transformation. *Infertility* - Infertility, particularly anovulatory infertility, is often associated with **unopposed estrogen exposure** due to a lack of progesterone production. - This hormonal imbalance can lead to endometrial hyperplasia and an increased risk of developing endometrial cancer. *Tamoxifen* - Tamoxifen, a **selective estrogen receptor modulator (SERM)**, acts as an estrogen antagonist in breast tissue but as an estrogen agonist in the endometrium. - This estrogenic effect on the endometrium can lead to **endometrial hyperplasia** and increase the risk of endometrial cancer, particularly when used long-term. [Practice more Obstetrics and Gynecology PYQs on OnCourse]

Q: In which period is maternal mortality highest?

Peripartum. ***Peripartum*** - The peripartum period encompasses the time immediately before, during, and after childbirth, when the risks of **hemorrhage, infection, pre-eclampsia/eclampsia**, and other **acute obstetric complications** are highest. - The **physiological stresses** of labor and delivery, coupled with potential complications like **uterine atony** or **obstructed labor**, contribute significantly to maternal mortality during this critical window [2]. *Antepartum* - While complications like **severe pre-eclampsia, ectopic pregnancy**, and chronic conditions can occur during the antepartum period, the **acute risks of hemorrhage and infection** are generally lower than during and immediately after delivery [1]. - Most maternal deaths occurring antepartum are due to conditions that ultimately lead to or manifest more severely during the peripartum or postpartum phases, such as undetected pre-eclampsia worsening to eclampsia [3]. *Postpartum* - The postpartum period (especially the first 42 days) also carries significant risks such as **late postpartum hemorrhage, puerperal sepsis, and thromboembolism** [2]. - While substantial, the **magnitude of mortality risk** primarily due to acute events related to labor and delivery (e.g., massive hemorrhage, amniotic fluid embolism) is often concentrated in the peripartum period [2]. *No period of maximum risk* - This statement is incorrect because maternal mortality risk is demonstrably **higher during specific periods** related to pregnancy and childbirth, rather than being evenly distributed [1]. - The physiological changes and obstetric challenges associated with gestation, labor, and the puerperium create distinct periods of elevated risk for maternal morbidity and mortality. [Practice more Obstetrics and Gynecology PYQs on OnCourse]

Question 1

The thickness of the endometrium at the time of implantation is:

Accepted Answer

7 - 10 mm

Answer

20 - 30 mm

Answer

30 - 40 mm

Answer

3 - 4 mm

Question 2

What is the most common primary malignancy of the fallopian tube?

Accepted Answer

Serous carcinoma

Answer

Squamous cell carcinoma

Answer

Teratoma

Answer

Choriocarcinoma

Question 3

Which of the following is the MOST CRITICAL indication for Acyclovir use during pregnancy?

Accepted Answer

Treatment of disseminated herpes

Answer

Treatment of chickenpox in the first trimester

Answer

Prophylaxis for recurrent herpes during pregnancy

Answer

Prevention of cytomegalovirus infection in pregnancy

Question 4

Which of the following is not a recognized risk factor for endometrial carcinoma?

Accepted Answer

Smoking

Answer

Infertility

Answer

Obesity

Answer

Tamoxifen

Question 5

In which period is maternal mortality highest?

Accepted Answer

Peripartum

Answer

Antepartum

Answer

Postpartum

Answer

No period of maximum risk

Question 6

What is the energy requirement in late pregnancy?

Accepted Answer

2500 calories

Answer

2000 calories

Answer

1400 calories

Answer

3000 calories

Question 7

A 35-year-old woman presents with 4 months of amenorrhea, increased FSH, LH, and decreased estrogen. What is the most likely diagnosis?

Accepted Answer

Premature ovarian insufficiency

Answer

Menopause

Answer

Late menopause

Answer

Perimenopause

Question 8

At which stage of cervical cancer is hydronephrosis typically observed?

Accepted Answer

Stage 3B

Answer

Stage 2A

Answer

Stage 2B

Answer

Stage 3A

Question 9

What is the most common complication that can arise from vacuum delivery during childbirth?

Accepted Answer

Cephalohematoma

Answer

Subgaleal hemorrhage

Answer

Scalp lacerations

Answer

Retinal hemorrhages

Question 10

Which of the following statements about tuberculosis (TB) of the uterus is NOT true?

Accepted Answer

Most common is ascending infection

Answer

Increase incidence of ectopic pregnancy

Answer

Involvement of endosalpinx

Answer

Mostly secondary

NEET-PG 2012 — Obstetrics and Gynecology