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FMGE 2010 — Pharmacology

Q: Antidote for benzodiazepine poisoning: FMGE 10, 13; NEET 14

Flumazenil. ***Flumazenil*** - **Flumazenil** is a competitive **benzodiazepine receptor antagonist** that can reverse the sedative and other central nervous system effects of benzodiazepines. - It works by blocking benzodiazepines from binding to their receptor sites on the **GABA-A receptor complex**. *Naloxone* - **Naloxone** is a competitive **opioid receptor antagonist** used to reverse opioid overdose. - It has no effect on **benzodiazepine toxicity** as it targets different receptor systems. *Atropine* - **Atropine** is an **anticholinergic drug** used to reverse the effects of **cholinergic poisoning** (e.g., from organophosphates, carbamates) or symptomatic bradycardia. - It works on muscarinic acetylcholine receptors and is not involved in benzodiazepine metabolism or action. *N-acetyl-cysteine* - **N-acetyl-cysteine (NAC)** is primarily used as an antidote for **acetaminophen (paracetamol) poisoning**, where it replenishes glutathione. - It is also used in some cases of mucolysis but has no role in reversing benzodiazepine toxicity. [Practice more Pharmacology PYQs on OnCourse]

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Antidote for benzodiazepine poisoning: FMGE 10, 13; NEET 14