Pharmacokinetics (ADME principles) — Flashcards
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1
Absorption factors and bioavailability
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2
Drug distribution and protein binding
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3
Volume of distribution concepts
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4
Phase I metabolism (oxidation, reduction, hydrolysis)
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5
Phase II metabolism (conjugation reactions)
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6
Cytochrome P450 system
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7
First-pass metabolism
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8
Renal excretion mechanisms
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9
Biliary excretion
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10
Half-life and steady state concepts
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11
Area under the curve calculations
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12
Dosing in renal impairment
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13
Dosing in hepatic impairment
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