Half-life and steady state concepts — Flashcards

Flashcard 1: What pharmokinetic term describes the theoretical volume occupied by total amount of drug in the body relative to its plasma concentration? _____

Answer: Volume of distribution (Vd)

Flashcard 2: To calculate bioavailability using graphs of plasma concentration vs time utilizing nonintravenous vs intravenous administration, what is the formula?_____

Answer: F = (AUC oral x dose IV) / (AUC IV x dose oral)

Flashcard 3: What formula is used to calculate half-life (t1/2) in first-order elimination kinetics?

Answer: t1/2 = (0.693 × Vd) / CL

Extra: Where: - Vd = Volume of Distribution - CL = Clearance - 0.693 = ln(2) In first-order kinetics, half-life is constant and independent of the drug concentration.

Flashcard 4: In _____ order kinetics, the rate of reaction is directly proportional to the substrate (drug) concentration

Answer: first

Flashcard 5: Which drug elimination is characterized by a constant amount of drug eliminated per unit time?_____

Answer: Zero-order elimination