Absorption factors and bioavailability — Flashcards

Flashcard 1: What pharmokinetic term describes the theoretical volume occupied by total amount of drug in the body relative to its plasma concentration? _____

Answer: Volume of distribution (Vd)

Flashcard 2: Cardiovascular (Nitrates) _____ administration of nitroglycerine avoids first pass metabolism, which is useful for immediate relief of angina

Answer: Sublingual

Flashcard 3: Antacids can affect _____ of other drugs by altering gastric and urinary pH

Answer: pharmacokinetics (absorption and excretion)

Flashcard 4: Phase _____ drug metabolism usually yields slightly polar, water-soluble metabolites (often still active)

Answer: I

Flashcard 5: Which drug elimination is characterized by an exponential curve?_____

Answer: First-order elimination

Flashcard 6: What formula is used to calculate loading dose? _____

Answer: (Cp × Vd) / F

Extra: Cp = Target plasma concentration Vd = Volume of distribution F = Bioavailability Note: Loading dose depends on the **volume of distribution** (Vd). In contrast, maintenance dose depends on **clearance** (CL).

Flashcard 7: Phase _____ drug metabolism usually yields very polar, water-soluble metabolites (inactive)

Answer: II