Antivirals — Flashcards

Flashcard 81: The NRTI _____ is classically associated with bone marrow suppression

Answer: Zidovudine (AZT)

Flashcard 82: Neuraminidase inhibitors are used to treat and prevent Influenza A and/or B and/or C? _____

Answer: A & B

Flashcard 83: NNRTIs are associated with _____ syndrome, a severe cutaneous pathology associated with the sloughing of skin

Answer: Stevens-Johnson

Extra: Toxic epidermal necrolysis/Stevens-Johnson syndrome This 6-month-old patient presents with toxic epidermal necrolysis, the severe form of Stevens-Johnson syndrome. Smallpox vaccination can trigger toxic epidermal necrolysis. Stevens-Johnson syndrome following sulfonamide treatment Blistering of skin and epidermal detachment involving the conjunctiva are visible, resembling a superficial burn.

Flashcard 84: Foscarnet has been shown to inhibit HIV _____

Answer: Reverse Transcriptase

Flashcard 85: Ganciclovir must be _____ by intracellular enzymes to reach its activated nucleotide form

Answer: phosphorylated three times

Flashcard 86: Cidofovir is an antiviral drug that is _____-toxic

Answer: nephro

Flashcard 87: What is the mechanism of resistance to Acyclovir/Famciclovir/Valacyclovir? _____

Answer: Mutated/Absent Thymidine Kinase

Flashcard 88: Resistance in CMV to ganciclovir occurs with mutations in the _____ gene

Answer: UL97

Flashcard 89: Which type of HAART drug is tenofovir (TDF)? _____

Answer: NRTI

Flashcard 90: Patients taking Foscarnet can experience various _____ abnormalities

Answer: electrolyte