Antifungals — Flashcards

Flashcard 51: _____azole is used for systemic infections with dimorphic fungi

Answer: Itracon

Flashcard 52: Griseofulvin is a(n) _____ of CYP-450

Answer: inducer

Flashcard 53: Azoles inhibit the conversion of _____ to _____

Answer: lanosterol

Flashcard 54: Azoles can cause anti-androgenic side effects, most commonly resulting in _____

Answer: gynecomastia

Flashcard 55: Terbinafine is associated with side effects of GI upset, headaches, hepatotoxicity, and _____ disturbance

Answer: taste

Flashcard 56: Which antifungal is fungistatic? _____

Answer: Griseofulvin

Flashcard 57: Azoles work by inhibiting _____ enzymes in the Fungi

Answer: cytochrome P450

Extra: Ergosterol is a component of the fungal cell membrane. The cell wall contains chitin and β-glucans (targeted by echinocandins).

Flashcard 58: _____ (e.g., Amphotericin B, Nystatin) disrupt fungal cell membrane integrity by binding to ergosterol and forming pores.

Answer: Polyenes

Extra: Mechanism: Bind ergosterol (unique to fungi); form membrane pores that allow leakage of electrolytes.

Flashcard 59: Local, mild infections of Blastomycosis are treated with _____ drugs, e.g. _____

Answer: -azole

Flashcard 60: To decrease toxicity of amphotericin B, use a(n) _____ formulation and give with IV normal saline

Answer: liposomal