Antifungal spectrum of activity — Flashcards

Flashcard 1: Which antifungal agent inhibits fungal DNA and RNA synthesis?

Answer: Flucytosine

Flashcard 2: Angioinvasive aspergillosis is treated with _____

Answer: Voriconazole

Flashcard 3: What is the pharmacological treatment of Mucormycosis?_____

Answer: Amphotericin B

Flashcard 4: Which antifungal is used in severe, systemic fungal infections?_____

Answer: Amphotericin B

Flashcard 5: Which drug is used in the chronic maintenence therapy of Cryptococcal meningitis?_____

Answer: Fluconazole

Flashcard 6: Which class of antifungals inhibits the synthesis of β-glucan?

Answer: Echinocandins

Flashcard 7: Which azole antifungal is most notorious for the non-selective inhibition of human CYP450 enzymes?

Answer: Ketoconazole

Flashcard 8: ketoconazole

Answer: antiandrogen

Extra: hirsutism of PCOSgeneral inhibition of steroid synthesisgynecomastian, amenorrhea

Flashcard 9: Griseofulvin inhibits the action of fungal cell _____

Answer: microtubules

Extra:    https://onlinemeded.org/spa/microbiology/fungi/acquire?ref=anki 

Flashcard 10: For more severe Tinea infections or persistent Onychomycosis (manifestations of dermatophytes), oral _____ is used

Answer: Griseofulvin

Extra:   Watch Epidermophyton spp., Trichophyton spp., Microsporum spp. (dermatophytes) [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-fungi/videos/medical-microbiology-fungi-cutaneous-mycoses-epidermophyton-spp-trichophyton-spp-microsporum-spp-dermatophytes?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/dermatology/superficial-skin-infections/acquire?ref=anki