Antifungals — Flashcards

Flashcard 101: Specific indications for caspofungin include RACE: R_____ Azole-resistant Candida Candidemia Empiric treatment in a(n) febrile, neutropenic patient

Answer: efractory aspergillosis

Flashcard 102: Echinocandins are antifungal agents that act at the cell _____

Answer: wall

Flashcard 103: Amphotericin B causes a dose-dependent / slow-accumulated Type _____ Renal Tubular Acidosis

Answer: 1

Flashcard 104: Amphotericin B use is associated with _____ toxicity

Answer: renal

Flashcard 105: What is the standard treatment of Cryptococcal meningitis? _____

Answer: Amphotericin B and Flucytosine

Flashcard 106: Malassezia furfur = _____ or selenium sulfide (selsun blue)

Answer: azoles (topical)

Flashcard 107: Is primary prophylaxis against cryptococcus recommended for patients with HIV? _____

Answer: No

Flashcard 108: Oral antifungals are generally required for: _____ Onychomycosis

Answer: Tinea capitis

Extra: Oral therapy (e.g., terbinafine, griseofulvin, itraconazole) is required for tinea capitis and onychomycosis because topical agents cannot penetrate the hair shaft or nail bed sufficiently.

Flashcard 109: Drug of choice for common candidal infections (e.g., esophageal, vulvovaginal)? _____

Answer: Fluconazole

Extra: Fluconazole is the drug of choice for most localized candidal infections. For invasive candidiasis (candidemia), echinocandins (e.g., caspofungin) are generally preferred as first-line therapy.

Flashcard 110: _____azole and _____azole are commonly used for topical fungal infections such as Tinea

Answer: Clotrim