Antifungals — Flashcards

Flashcard 91: Azoles can cause side effects of dizziness, nausea, vomiting, and _____toxicity

Answer: hepato

Extra: Hepatotoxicity and GI upset are common side effects of azole antifungals.

Flashcard 92: Polyenes disrupt cell membrane stability by binding _____

Answer: ergosterol

Extra: Polyenes (e.g., amphotericin B, nystatin) bind to ergosterol in the fungal cell membrane, forming pores that cause leakage of electrolytes (especially potassium) and cell death.

Flashcard 93: Amphotericin B related renal toxicity results in _____ due to decreased erythropoietin production

Answer: anemia

Flashcard 94: Tinea capitis in children is treated with _____ or _____

Answer: oral griseofulvin

Flashcard 95: Can Nystatin be given for systemic fungal infections? _____

Answer: No

Flashcard 96: Which antifungal can cause a disulfiram-like reaction? _____

Answer: Griseofulvin

Flashcard 97: Echinocandins are primarily metabolized via the _____

Answer: liver

Flashcard 98: What is the treatment of choice for Naegleria fowleri? _____

Answer: Amphotericin B

Flashcard 99: Griseofulvin is a cytochrome p450 _____

Answer: inducer

Flashcard 100: Specific indications for caspofungin include RACE: R_____ Azole-resistant Candida Candidemia Empiric treatment in a(n) febrile, neutropenic patient

Answer: efractory aspergillosis