Antibiotics — Flashcards

Flashcard 731: How does MRSA obtain methicillin resistance? Alters _____

Answer: PBP (penicillin-binding proteins)

Flashcard 732: Which antibiotic depolarizes bacterial cell membranes via creation of transmembrane channels?_____

Answer: Daptomycin

Flashcard 733: What gout drug can precipitate the side effects of penicillins?_____

Answer: Probenecid

Flashcard 734: Which antibiotic causes the misreading of mRNA and inhibition of translation?_____

Answer: Aminoglycosides

Flashcard 735: What step of bacterial protein synthesis is inhibited by **Clindamycin**?

Answer: Inhibits **translocation** by binding to the **50S** ribosomal subunit.

Extra: Clindamycin's mechanism is similar to macrolides (e.g., erythromycin). It binds to the 50S subunit, preventing the movement of the ribosome along the mRNA (translocation).

Flashcard 736: Mupirocin is a topical antibiotic that works by inhibiting _____

Answer: isoleucine t-RNA synthetase

Flashcard 737: Which aminoglycosides (3) are used to treat septicemia, respiratory tract infections and UTIs caused by gram negatives?_____

Answer: Gentamicin, Tobramycin, Amikacin

Flashcard 738: Which anti-microbial class is Aztreonam particularly synergistic with?_____

Answer: Aminoglycosides

Flashcard 739: Empiric treatment of Pasteurella multocida is with _____

Answer: penicillin

Flashcard 740: TMP-SMX are _____ and should be avoided due to inhibition of folate metabolism

Answer: teratogenic