Antibiotics — Flashcards

Flashcard 651: Which Topoisomerases do Fluoroquinolones inhibit?_____

Answer: II and IV

Flashcard 652: Rifampin is given with Dapsone because it _____ to Dapsone

Answer: delays resistance

Flashcard 653: What gram negative species are covered by 2nd generation cephalosporins?_____

Answer: H. influenzae, Enterobacter aerogenes, Neisseria spp., Serratia marcescens (HENS) + PEcK

Flashcard 654: Which aminoglycoside is used in bowel prep before colorectal surgery?_____

Answer: Neomycin

Flashcard 655: What class of beta-lactam antibiotics are indicated in drug-resistant infections?_____

Answer: Carbapenems

Flashcard 656: Which enzyme is inhibited by sulfamethoxazole (SMX)?_____

Answer: Dihydropteroate synthase (prokaryotic)

Flashcard 657: Which carbapenem is stable to dehydropeptidase I?_____

Answer: Meropenem

Flashcard 658: Which specific process of bacterial protein synthesis is inhibited by **Macrolides**?

Answer: Translocation (50S ribosomal subunit inhibition)

Extra: Macrolides (e.g., Azithromycin, Erythromycin) bind to the 23S rRNA of the 50S subunit, blocking the translocation step where the peptidyl-tRNA moves from the A-site to the P-site.

Flashcard 659: What is the treatment for Actinomyces infection?_____

Answer: Penicillin G

Flashcard 660: What is the treatment of Leptospirosis?_____

Answer: Penicillin G