Antibiotics — Flashcards

Flashcard 461: Sulfonamides _____ cytochrome P450

Answer: inhibit

Flashcard 462: _____ are a class of antibiotics that can possibly cause leg cramps and myalgias along with cartilage damage

Answer: Fluoroquinolones

Flashcard 463: Isoniazid is a(n) _____ of CYP-450

Answer: inhibitor

Flashcard 464: What class of bacterial genetics inhibitors can be used to treat anthrax? _____

Answer: Fluoroquinolones

Flashcard 465: Which protein synthesis inhibitor can cause dose-independent aplastic anemia? _____

Answer: Chloramphenicol

Flashcard 466: Are **MRSA** and **Enterococcus** (*E. faecalis*) covered by 5th generation cephalosporins (e.g., ceftaroline)? _____

Answer: YES

Extra: Cephalosporins are generally not active against **L**isteria, **A**typicals (Chlamydia, Mycoplasma), **M**RSA, and **E**nterococci (**LAME**). **Ceftaroline** (5th gen) is the exception that covers **MRSA** and ***E. faecalis***. It does **not** cover *Listeria* or *Pseudomonas*.

Flashcard 467: What is the treatment for MRSA (methicillin resistant staphylococcus aureus)? _____

Answer: Vancomycin

Flashcard 468: What is the antibiotic treatment for S. epidermidis prosthetic valve endocarditis? (3) _____

Answer: Vancomycin + rifampin for >= 6 weeks + gentamicin for 2 weeks

Extra: Surgical valve replacement may be required.

Flashcard 469: _____ and _____ are first generation cephalosporins that can be used to treat skin/soft tissue infections by Staph/Strep

Answer: Cephalexin

Flashcard 470: What tuberculosis drug is most commonly associated with liver injury? _____

Answer: Isoniazid