Antibiotics — Flashcards

Flashcard 381: Upon rapid infusion of **Vancomycin**, what side effect is occurring if the patient presents with diffuse flushing of the face, neck, and upper torso? _____

Answer: Red Man Syndrome

Extra: Red man syndrome (Vancomycin flushing syndrome) is a rate-dependent reaction. It is recommended to infuse vancomycin at a rate of no more than 10 mg/min or over at least 60 minutes to prevent this occurrence. Unlike a true allergy, it can often be managed by slowing the infusion rate and administering antihistamines.

Flashcard 382: Helicobacter pylori triple therapy includes a PPI, _____, and clarithromycin

Answer: amoxicillin/metronidazole

Flashcard 383: Which RIPE therapy drug can cause drug-induced lupus? _____

Answer: Isoniazid

Flashcard 384: Aminoglycosides are actively transported into the cell via a(n) _____-dependent process

Answer: oxygen

Extra: Aminoglycosides require oxygen-dependent transport (via the electron transport chain) to enter the bacterial cell; thus, they are ineffective against anaerobic bacteria.

Flashcard 385: What is the first line treatment for a patient with H. pylori infection? _____

Answer: Triple therapy with proton pump inhibitors (PPIs) + clarithromycin + amoxicillin or metronidazole

Extra: Sketchy Pharmacology: GI (Gastroesophageal Refund)

Flashcard 386: What suffix is associated with Macrolide antibiotics? _____

Answer: -thromycin

Flashcard 387: What is the treatment of MSSA Staph aureus right-sided endocarditis? _____

Answer: Anti-staph penicillins (nafcillin, oxacillin, dicloxacillin, methicillin)

Flashcard 388: Which generation of Cephalosporins is Cefepime? _____

Answer: 4th Generation

Flashcard 389: Anti-_____ drugs, such as dapsone, may induce oxidative stress and are thus contraindicated in patients with G6PD deficiency

Answer: leprotic

Flashcard 390: Cephalosporins are what class of antibiotic? _____

Answer: β-lactam