Antibiotics — Flashcards

Flashcard 241: What is the treatment of primary, secondary and latent syphilis (Treponema pallidum)? _____

Answer: Benzathine penicillin G (intramuscular)

Flashcard 242: Treatment of Gardnerella vaginalis includes metronidazole and _____

Answer: clindamycin

Flashcard 243: Fluoroquinolones are indicated for treatment of Otitis _____

Answer: Externa

Flashcard 244: Which antibiotics can result in acute tubular necrosis? _____

Answer: Aminoglycosides

Flashcard 245: What is the first-line treatment of complicated UTIs? _____

Answer: Fluoroquinolones

Flashcard 246: Fluoroquinolone-associated disabling side effects (e.g., tendinopathy) are most likely mediated by _____ toxicity

Answer: mitochondrial

Extra: Common (non-disabling) side effects of fluoroquinolones include GI upset and skin rashes. Severe disabling effects involve tendons (tendinopathy/rupture), nerves (peripheral neuropathy), and the heart (QT prolongation).

Flashcard 247: Which antibiotics bind the 50S ribosomal subunit suppressing translocation? _____

Answer: Clindamycin; Macrolides

Flashcard 248: Hematological complications of Trimethoprim (TMP) use include _____ (granulocytopenia, leukopenia) and megaloblastic anemia

Answer: pancytopenia

Flashcard 249: Vancomycin can cause a potentially fatal delayed hypersensitivity reaction known as _____ syndrome

Answer: DRESS

Extra: DRESS syndrome: Drug Reaction with Eosinophilia and Systemic Symptoms.

Flashcard 250: _____ generation cephalosporins are able to penetrate the CNS

Answer: 3rd