Inflammation — Flashcards

Flashcard 21: The combination of dilatation (aneurysms) and narrowing (fibrosis) in polyarteritis nodosa gives blood vessels a(n) _____ appearance on imaging

Answer: "string of pearls"

Extra: * due to different stages of inflammation in different areas * "string of beads" appearance - fibromuscular dysplasia Atlas:

Flashcard 22: What type of hypersensitivity reaction is chronic autoimmune gastritis? _____

Answer: Type IV (T-cell mediated)

Extra: * This is not peculiar to autoimmune gastritis, most autoimmune diseases are also type 4 hypersensitivity reactions but they have positive antibodies in the serum which have diagnostic significance. The way I think of it, after these cells have been destroyed by the cellular immune response, intracellular antigens are taken up by B cells which differentiate and secrete antibodies against these antigens* Atlas:

Flashcard 23: Which arthritis, osteoarthritis or rheumatoid arthritis, is characterized by inflammatory synovial fluid (WBC > 5000/mm3)? _____

Answer: Rheumatoid arthritis

Flashcard 24: _____ leprosy is associated with a strong Th1-cell response, allowing for cell-mediated immunity

Answer: Tuberculoid

Flashcard 25: Acute inflammation typically results in resolution and healing, which is mediated by _____ and TGF-β

Answer: IL-10

Flashcard 26: Gallbladder distension, pressure necrosis, and perforation may occur in _____ due to worsening inflammation.

Answer: acute cholecystitis

Extra: Gallbladder distension increases intraluminal pressure, which can lead to ischemia, pressure necrosis, and perforation.

Flashcard 27: What is the most common cause of chronic inflammation? _____

Answer: Persistent infection

Flashcard 28: One cardinal sign of inflammation is _____, or loss of function

Answer: Functio laesa

Flashcard 29: _____ are liver produced factors whose serum concentrations change significantly in response to inflammation

Answer: Acute phase reactants

Flashcard 30: Histologically, Hashimoto thyroiditis is associated with chronic inflammation with well-developed _____

Answer: germinal centers

Extra: Atlas: