Inflammation — Flashcards

Flashcard 131: Mast cells may be activated by cross-linking of cell-surface _____ by antigen

Answer: IgE

Flashcard 132: Left shifts are usually seen with neutrophilia in the acute response to _____ or tissue necrosis

Answer: bacterial infection

Flashcard 133: Which arthritis is characterized by joint space narrowing, erosions, and periarticular osteopenia on imaging? _____

Answer: Rheumatoid arthritis

Extra: Atlas:

Flashcard 134: The pathogenesis of Gout/Pseudogout involves Pattern Recognition Receptors detecting crystalline deposits (uric acid / calcium pyrophosphate) in joints, which in response leads to an inflammatory cascade mediated by IL-1, causing the joint to be invaded by _____

Answer: neutrophils

Flashcard 135: In Riedel's thyroiditis, release of _____ leads to fibroblast activation and fibrosis

Answer: cytokines (e.g. TGF-β, IL-13)

Flashcard 136: _____ can trigger autoimmunity (e.g. cigarette smoke -> rheumatoid arthritis); environmental factors may also trigger autoimmunity

Answer: Toxins

Flashcard 137: Asthma pathogenesis: TH2 cells secrete IL-_____ which mediates class switching to IgE

Answer: 4

Flashcard 138: Early lesions of polyarteritis nodosa are characterized by transmural inflammation with _____

Answer: fibrinoid necrosis

Extra: * Late lesions of polyarteritis nodosa are characterized by fibrosis Atlas:

Flashcard 139: Acute interstitial nephritis may present with _____ casts in the urine

Answer: WBC

Extra: Acute interstitial nephritis (AIN) is classically associated with eosinophils and WBC casts in the urine.

Flashcard 140: Which cells release proteolytic enzymes in response to brain abscess, causing liquefactive necrosis? _____

Answer: Neutrophils