Viruses — Flashcards

Flashcard 311: Condylomata acuminata (genital warts) is associated with HPV strains _____ and _____

Answer: 6

Extra:  https://onlinemeded.org/spa/obgyn?ref=anki 

Flashcard 312: Test of choice for HSV = _____

Answer: PCR

Extra:  https://onlinemeded.org/spa/infectious-disease/genital-ulcers/acquire?ref=anki 

Flashcard 313: SSPE (subacute sclerosing panencephalitis) is seen 5-15 years after infection with _____

Answer: measles (rubeola)

Extra:  https://onlinemeded.org/spa/pediatrics/peds-infectious-rashes/acquire?ref=anki 

Flashcard 314: Coxsackie A is associated with _____ (mouth blisters in the posterior pharynx)

Answer: herpangina

Extra:  https://onlinemeded.org/spa/infectious-disease?ref=anki 

Flashcard 315: _____ is a dsRNA reovirus that is a major cause of acute watery diarrhea in the USA during the winter, especially in day-care centers and kindergartens (babies/toddlers)

Answer: Rotavirus

Extra:  https://onlinemeded.org/spa/gastroenterology/acute-diarrhea/acquire?ref=anki 

Flashcard 316: Which class of helper T cell helps maintain specific immune tolerance by suppressing CD4 and CD8 T-cell effector functions? _____

Answer: Regulatory T (TReg) cells

Flashcard 317: Which class of helper T cell secretes IL-17, -21, and -22? _____ *What does each do?

Answer: Th17 • **IL-17**: Recruits neutrophils (inflammation) • **IL-21**: Autocrine stimulation (promotes Th17 differentiation) • **IL-22**: Maintains epithelial barrier integrity

Extra: Th17 cells are primarily involved in the host defense against extracellular bacteria and fungi. • **Induced by**: TGF-β, IL-6 • **Inhibited by**: IFN-γ, IL-4 • **Clinical correlation**: STAT3 mutations lead to deficiency in Th17 cells, causing **Hyper-IgE (Job) syndrome** (characterized by "cold" staphylococcal abscesses and chronic candidiasis).

Flashcard 318: How many identical antigens can a single IgM molecule bind?_____

Answer: 10

Flashcard 319: Which class of helper T cell activates macrophages and cytotoxic T cells?_____

Answer: Th1

Flashcard 320: Which class of helper T cell secretes TGF-B, IL-10, and IL-35? _____

Answer: Regulatory T cell