Molecular Genetics — Flashcards

Flashcard 731: Tumor suppressor genes _____ cell growth

Answer: regulate

Flashcard 732: Which end of the DNA strand does the DNA primer bind to during PCR?_____

Answer: 3' end

Flashcard 733: The RB tumor suppressor protein is located on chromosome _____

Answer: 13

Flashcard 734: If different mutations at the same locus produce the same phenotype, a disease has _____

Answer: allelic heterogeneity

Flashcard 735: Topoisomerase _____ induces breaks in single strands of DNA

Answer: I

Flashcard 736: What is another name for prokaryotic topoisomerase II? _____

Answer: DNA gyrase

Flashcard 737: Mutation in the sonic hedgehog gene can cause _____

Answer: holoprosencephaly (specific/head)

Flashcard 738: Hemoglobin C disease is caused by a mutation in the _____ chain of hemoglobin

Answer: Beta (β) globin

Extra: Hemoglobin C (HbC) is caused by a missense mutation in the **β-globin** gene, resulting in the substitution of **glutamic acid** with **lysine** at position 6 (Glu6Lys). Mnemonic: Ly**C**ine for Hb**C**; **V**al**S**ine for Hb**S**.

Flashcard 739: Cyclin D1 sits on chromosome _____

Answer: 11

Flashcard 740: What form of chromatin is less condensed? _____

Answer: Euchromatin