Molecular Genetics — Flashcards

The mitochondrial (intrinsic) pathway of apoptosis occurs via inactivation of _____

A mutation in Rb results in constitutively free _____, leading to uncontrolled cell cycle progression

What is the mode of inheritance of Gitelman syndrome? _____

What is the mode of inheritance of Bruton agammaglobulinemia? _____

What is the inheritance of Menkes disease? _____

A _____ system can inducibly manipulate genes at specific developmental points (e.g. study a gene whose deletion causes embryonic deaths)

Insulin is packaged in secretory granules of the Golgi apparatus with _____

What is the mode of inheritance of leukocyte adhesion deficiency? _____

_____ sex is defined by the sex chromosomes, XY in males and XX in females

Mutations in PTEN lead to overactivity of _____ proto-oncogene