Molecular Genetics US Medical PG Flashcards - Medical Study Cards
Master Molecular Genetics with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Molecular Genetics Flashcard Deck - 10 Cards
Flashcard 321: Hemophilia A can arise from a(n) _____ mutation without any family history (20%)
Answer: new (de novo)
Extra: Approximately 1/3 of cases of Hemophilia A are due to de novo mutations, meaning there is no prior family history.
Note: Acquired Hemophilia A is a distinct clinical entity caused by autoantibodies against Factor VIII; it is associated with pregnancy, autoimmune diseases (e.g., SLE, RA), and certain drugs (e.g., PCN).
Flashcard 322: Which prokaryotic polymerase has both 3 to 5' exonuclease activity and 5' to 3' exonuclease activity?
_____
Answer: DNA polymerase I
Extra:
Watch DNA Replication [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-molecular-biology/videos/medical-biochemistry-molecular-biology-dna-dna-replication?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-replication-transcription-and-translation?index=6]
https://onlinemeded.org?ref=anki
Flashcard 323: Which pyrimidine is characterized by the presence of methyl groups, but no amino group at the 12 o'clock position?
_____
Answer: Thymine
Extra:
https://onlinemeded.org?ref=anki
Flashcard 324: Which type of receptor is associated with growth hormone?
_____
Answer: Receptor associated tyrosine kinase
Extra:
Sketchy Pharmacology: Thyroid, Pituitary, & Adrenal
Watch Growth hormone, mecasermin, octreotide, pegvisomant [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-gi-endocrine/videos/medical-pharmacology-gi-and-endocrine-hypothalamic-and-pituitary-growth-hormone-mecasermin-octreotide-pegvisomant?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
https://onlinemeded.org/spa/endocrinology?ref=anki
Flashcard 325: A(n) _____ transgenic mouse has had a gene inserted
Answer: knock-in
Extra:
https://onlinemeded.org?ref=anki
Flashcard 326: In sickle cells, the mutated hemoglobin molecules overlap due to increased _____ interactions between hemoglobin molecules
Answer: hydrophobic/nonpolar
Extra:
* due to replacement of negatively charged glutamic acid with NONPOLAR valine
https://onlinemeded.org/spa/pediatrics/sickle-cell-disease/acquire?ref=anki
Flashcard 327: Vitamins _____ and _____ are necessary for synthesis of DNA precursors
Answer: B9 (folate)
Extra:
Watch Megaloblastic Anemia: Folate Deficiency & Vitamin B Deficiency [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-blood-coagulation/videos/medical-pathophysiology-blood-and-coagulation-normocytic-and-macrocytic-anemias-megaloblastic-anemia-folate-deficiency-and-vitamin-b12-deficiency?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/macrocytic-anemia?index=2]
https://onlinemeded.org/spa/hematology-oncology/macrocytic-anemia/acquire?ref=anki
Other:
Flashcard 328: X-linked recessive diseases are commonly more severe in _____
Answer: males
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/basics-of-clinical-genetics?index=4]
https://onlinemeded.org/spa/genetics/modes-of-inheritance/acquire?ref=anki
Flashcard 329: What is the most common mechanism of chromosomal aneuploidy?
_____
Answer: Meiotic nondisjunction
Extra:
https://onlinemeded.org/spa/genetics?ref=anki
Flashcard 330: The intracellular receptors for steroid hormones, thyroid hormones, and vitamins A/D use _____ motifs to bind DNA.
Answer: zinc finger
Extra: Zinc finger motifs are the most common DNA-binding domain. Receptors for steroid hormones, thyroid hormones, and vitamins A/D (fat-soluble) belong to the nuclear receptor superfamily and act as transcription factors.
Keywords: Molecular Genetics flashcards, medical flashcards, NEET PG preparation, USMLE Step 1 flashcards, Anki alternative, spaced repetition medical, OnCourse flashcards
