Molecular Genetics — Flashcards

Flashcard 181: What type of oncogene is BRAF? _____

Answer: Serine/threonine kinase

Flashcard 182: Which hemoglobin type migrates the least far from the negative electrode on electrophoresis? _____

Answer: HbC

Extra: Atlas:

Flashcard 183: What is the mode of inheritance of protein C or S deficiency? _____

Answer: Autosomal dominant

Flashcard 184: If a uniparental disomy results in a(n) heterozygous offspring, there may have been a(n) _____ error

Answer: meiosis I

Flashcard 185: What process is used embryologically to cause "Lyonization" _____

Answer: DNA Methylation

Flashcard 186: In epigenetics, when a histone is _____, the histone unwinds the DNA to make it available for transcription

Answer: acetylated

Extra: #REF!

Flashcard 187: When in the hypophosphorylated state, Rb sequesters _____, which is necessary for transition to the S phase

Answer: E2F transcription factor

Flashcard 188: What is the most common mode of inheritance of pyruvate dehydrogenase deficiency? _____

Answer: X-linked

Extra: Pyruvate dehydrogenase complex deficiency is most commonly caused by an X-linked mutation in the PDHA1 gene (E1-alpha subunit). Although inherited on the X chromosome, it often presents in females due to skewed X-inactivation (lyonization), which is why it is often described as X-linked dominant.

Flashcard 189: One feature of the genetic code is that it is _____: it is read from a fixed starting point as a continuous sequence of bases

Answer: commaless, nonoverlapping

Flashcard 190: What tumor suppressor does the E7 protein from Human Papillomavirus (HPV) bind to and inhibit? _____

Answer: Rb (specifically p105-Rb)