Molecular Genetics — Flashcards

Flashcard 171: What sequence of bases represents a polyadenylation signal? _____

Answer: AAUAAA

Extra: Watch associated Bootcamp video

Flashcard 172: Which immunoglobulin is released into breast milk (colostrum)? _____

Answer: IgA

Flashcard 173: What is the most common mechanism of chromosomal aneuploidy? _____

Answer: Meiotic nondisjunction

Flashcard 174: How many ring(s) do pyrimidines have? _____

Answer: One

Flashcard 175: What is the inheritance of Romano-Ward syndrome (a form of long QT syndrome)? _____

Answer: Autosomal dominant

Flashcard 176: β-thalassemia is often due to mutations in _____ and promoter sequences

Answer: splice sites

Extra: β-thalassemia is typically caused by point mutations in the β-globin gene (in contrast to α-thalassemia, which is usually caused by gene deletions). Mechanisms: * **Splice site mutations**: Lead to defective mRNA processing (can result in β⁰ or β⁺ thalassemia). * **Promoter mutations**: Lead to decreased initiation of transcription (typically result in β⁺ thalassemia). Note: Nonsense mutations (leading to premature stop codons) can also cause β-thalassemia, but they occur in the coding regions (exons), not the promoter.

Flashcard 177: With H1, the nucleosome exists as _____ nm chromatin

Answer: 30

Flashcard 178: What is the mode of inheritance of medium chain acyl-CoA dehydrogenase (MCAD) deficiency? _____

Answer: Autosomal recessive

Flashcard 179: Dopamine in the synapse is transported back into the nerve terminal via the _____ transporter

Answer: (DAT) dopamine

Extra: Sketchy Pharmacology: Autonomics (Indirect Sympathomimetics)

Flashcard 180: What type of oncogene is BRAF? _____

Answer: Serine/threonine kinase