Molecular Genetics — Flashcards

Flashcard 91: _____ scores are used to calculate the probability that two loci are linked

Answer: LOD

Extra: LOD stands for Logarithm of the Odds. A LOD score of 3 or higher is typically considered evidence that two loci are linked.

Flashcard 92: What is the mode of inheritance of Gaucher disease? _____

Answer: Autosomal recessive

Extra: Atlas:

Flashcard 93: When using ELISA, detection involves the use of a(n) _____ linked to a(n) enzyme

Answer: antibody

Flashcard 94: What is the penetrance of neurofibromatosis I? _____

Answer: 100%

Extra: Atlas:

Flashcard 95: The G1 restriction point of the cell cycle is regulated by the tumor suppressors _____ and _____

Answer: p53

Flashcard 96: Factor V Leiden is due to a point mutation near the _____ site of factor V

Answer: cleavage

Extra: * thus, protein C is unable to destroy activated factor V b/c there is no binding spot

Flashcard 97: One third of the collagen strand is made of the amino acid _____

Answer: glycine

Flashcard 98: Topoisomerase _____ induces breaks in both the positive and negative DNA strands (double stranded breaks)

Answer: II

Flashcard 99: A(n) _____ mutation occurs when a nucleotide substitution codes for a stop codon

Answer: nonsense

Flashcard 100: Generally, the 5' end of DNA or RNA is a(n) _____ group

Answer: phosphate