Metabolism — Flashcards

Flashcard 901: PTH stimulates the renal enzyme _____, which converts 25-hydroxycholecalciferol to the active form, 1,25-dihydroxycholecalciferol (vitamin D)

Answer: 1-hydroxylase

Flashcard 902: Pegademase is a PEGylated _____ used for treatment of the second most common form of SCID

Answer: Adenosine Deaminase

Flashcard 903: What type of collagen makes up skin and blood vessels? _____

Answer: Type III

Flashcard 904: What do the carrier molecules CoA and lipoamide carry in their activated forms? _____

Answer: Acyl groups

Flashcard 905: Each alpha- and beta-tubulin heterodimer of a microtubule has 2 _____ bound.

Answer: GTP

Extra: Alpha-tubulin binds GTP permanently (non-exchangeable), while beta-tubulin binds GTP reversibly and can hydrolyze it to GDP (exchangeable).

Flashcard 906: Purine de novo synthesis begins with _____

Answer: ribose-5-phosphate

Extra: Ribose-5-phosphate (derived from the HMP shunt) is converted to PRPP (phosphoribosyl pyrophosphate) by PRPP synthetase. PRPP then serves as the sugar-phosphate foundation for de novo purine synthesis.

Flashcard 907: Nicotinamides (NAD+, NADP+) come from Vitamin _____

Answer: B3

Flashcard 908: What proteins (2) have decreased activity due to vitamin K deficiency? _____

Answer: Protein C and protein S

Flashcard 909: Neurofibromin (from NF1) is a Ras _____

Answer: GTPase activating protein (GAP)

Flashcard 910: Which enzyme phosphorylates mannose in the Golgi apparatus, facilitating protein trafficking? _____

Answer: Phosphotransferase