Metabolism US Medical PG Flashcards - Medical Study Cards
Master Metabolism with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Metabolism Flashcard Deck - 10 Cards
Flashcard 611: What is the rate-limiting enzyme of de novo pyrimidine synthesis?
_____
Answer: Carbamoyl phosphate synthetase II
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-structure?index=8]
https://onlinemeded.org/spa/dna-to-protein/amino-acids/acquire?ref=anki
Flashcard 612: PEP carboxykinase is induced by _____ and cortisol
Answer: glucagon
Extra: PEPCK converts oxaloacetate to phosphoenolpyruvate. It is regulated by transcriptional induction (e.g., via glucagon/cAMP and cortisol).
Flashcard 613: Does hemolysis result in unconjugated or conjugated hyperbilirubinemia?
_____
Answer: Unconjugated
Extra:
* due to heme breakdown; high levels of UCB overwhelm the conjugating ability of the liver
Watch Lab Evaluation of Liver Injury & Hyperbilirubinemia [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pediatrics-hepatobiliary/videos/medical-pathophysiology-hepatobiliary-gallbladder-and-biliary-tract-disease-lab-evaluation-of-liver-injury-and-hyperbilirubinemia?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/pancreatic-and-biliary-pathology?index=9]
https://onlinemeded.org/spa/gastroenterology/jaundice/acquire?ref=anki
Flashcard 614: Collagen Synthesis: Hydroxylation of selected prolines and lysines during collagen synthesis requires vitamin _____
Answer: C
Extra:
Watch Collagen (Overview and Synthesis) [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-cell-biology/videos/medical-biochemistry-cell-biology-parts-of-cell-collagen-overview-and-synthesis?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
https://onlinemeded.org/spa/metabolism?ref=anki
Flashcard 615: Which amino acid may cause endothelial cell damage when serum levels are elevated?
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Answer: Homocysteine
Extra:
Watch Homocystinuria [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-metabolism/videos/medical-biochemistry-metabolism-amino-acids-and-proteins-homocystinuria?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
Watch Acquired & Inherited Thrombosis Syndromes [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-blood-coagulation/videos/medical-pathophysiology-blood-and-coagulation-coagulopathies-and-platelet-disorders-acquired-and-inherited-thrombosis-syndromes?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/coagulation-and-fibrinolysis?index=6]
https://onlinemeded.org/spa/heme-onc/hemostasis/acquire?ref=anki
Flashcard 616: Unconjugated bilirubin travels in the blood bound to _____
Answer: albumin
Extra:
Watch Lab Evaluation of Liver Injury & Hyperbilirubinemia [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pediatrics-hepatobiliary/videos/medical-pathophysiology-hepatobiliary-gallbladder-and-biliary-tract-disease-lab-evaluation-of-liver-injury-and-hyperbilirubinemia?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/physiology?index=10]
https://onlinemeded.org?ref=anki
UWorld:
Flashcard 617: Porphyria cutanea tarda is exacerbated by _____ consumption
Answer: alcohol
Extra: Susceptibility factors for Porphyria Cutanea Tarda (PCT) include: alcohol, smoking, hepatitis C (HCV), HIV, and iron overload.
Flashcard 618: Where in the cell does acetyl CoA production (from pyruvate) take place?
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Answer: Mitochondria
Extra:
Watch Pyruvate Dehydrogenase Complex [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-metabolism/videos/medical-biochemistry-metabolism-carbohydrates-pyruvate-dehydrogenase-complex?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
https://onlinemeded.org/spa/metabolism?ref=anki
Flashcard 619: Vitamin B3 (niacin) excess is associated with hyper-_____ and hyper-uricemia
Answer: glycemia
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/physiology?index=16]
https://onlinemeded.org/spa/metabolism?ref=anki
Flashcard 620: What differentiates **I-cell disease** from most other **lysosomal storage diseases**?\n_____
Answer: I-cell has a mixed accumulation of substrates forming inclusion bodies
Extra: I-cell disease (mucolipidosis II) is caused by a deficiency in N-acetylglucosaminyl-1-phosphotransferase, which is required to tag lysosomal enzymes with mannose-6-phosphate. Without this signal, enzymes are secreted instead of being sent to lysosomes. As a result, lysosomes lack multiple enzymes and accumulate a variety of undigested materials, seen as inclusion bodies.
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