Metabolism — Flashcards

Flashcard 11: HMP shunt

Answer: glucose-6-phosphate dehydrogenase (G6PD)

Flashcard 12: de novo pyrimidine synthesis

Answer: carbomoyl phosphate synthetase II

Flashcard 13: de novo purine synthesis

Answer: glutamine-PRPP amidotransferase

Flashcard 14: What enzyme converts pyruvate to acetyl-CoA?

Answer: pyruvate dehydrogenase complex (PDH)

Flashcard 15: What enzyme converts pyruvate to oxaloacetate?

Answer: pyruvate carboxylase (PC)

Flashcard 16: CO (carbon monoxide)

Answer:

Extra: inhibits electron transport chaininhibits oxidative phosphorylation

Flashcard 17: thermogenin

Answer:

Extra: endogenous protein, causes heat productioninhibits oxidative phosphorylation by increasing permeability of the mitochondrial membrane

Flashcard 18: gluconeogenesis

Answer: fructose-1,6-bisphosphatase

Extra: pyruvate carboxylase, PEP carboxylase, F-1,6-BPase, G6Pase mnemonic: Pathway Produces Fresh Glucose

Flashcard 19: oxidative phase of HMP shunt

Answer: G6PD

Flashcard 20: What initial substrate is common to the following four pathways? - to alanine via alanine aminotransferase (ALT) - to oxaloacetate via pyruvate carboxylase (PC) - to acetyl-CoA via pyruvate dehydrogenase complex (PDH) - to lactate via lactate dehydrogenase (LDH)

Answer: pyruvate