Metabolism — Flashcards

Flashcard 151: After release from iodinated thyroglobulin, MIT and DIT are _____ by the enzyme iodotyrosine dehalogenase, reproducing iodide (I-) and tyrosine

Answer: deiodinated

Flashcard 152: What clinical features are seen in 21-hydroxylase deficiency that are a result of increased androgen levels in males? _____

Answer: Precocious puberty

Extra: https://onlinemeded.org/spa/endocrinology/adrenals/acquire?ref=anki

Flashcard 153: _____ binds to the ferroportin transporter on intestinal mucosal cells and macrophages, thus inhibiting iron absorption

Answer: Hepcidin

Extra:  Watch Iron Deficiency Anemia & Anemia of Chronic Disease [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-blood-coagulation/videos/medical-pathophysiology-blood-and-coagulation-microcytic-anemias-iron-deficiency-anemia-and-anemia-of-chronic-disease?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/microcytic-anemia?index=4] https://onlinemeded.org?ref=anki 

Flashcard 154: Vibrio cholerae produces cholera toxin, which ADP-ribosylates and activates _____ resulting in a(n) increase in _____ in epithelial cells

Answer: Gs

Extra:  Watch Vibrio spp. [https://dashboard.sketchy.com/study/medical/courses/medical-microbiology/units/medical-microbiology-bacteria/videos/medical-microbiology-bacteria-gram-negative-bacilli-enteric-tract-vibrio-spp?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org?ref=anki 

Flashcard 155: _____ facilitate hydrolysis of GTP, decreasing the rate of G protein activation

Answer: GTPase activating proteins (GAPs)

Extra:   https://onlinemeded.org/spa/general-pharmacology/general-principles/acquire?ref=anki 

Flashcard 156: Conversion of isocitrate into α-ketoglutarate releases a molecule of _____ and _____

Answer: CO2

Extra:   Watch Citric Acid Cycle (TCA) [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-metabolism/videos/medical-biochemistry-metabolism-carbohydrates-tca-cycle?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/metabolism?ref=anki Other: 

Flashcard 157: Enzyme Replacement Therapy for _____ requires replacement of alpha-L-iduronidase

Answer: Hurler Syndrome

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/biochemistry/videos/lysosomal-storage-diseases?index=9] https://onlinemeded.org/spa/metabolism?ref=anki 

Flashcard 158: PDGF induces vascular remodeling and _____ cell migration

Answer: smooth muscle

Extra:  https://onlinemeded.org/spa/inflammation-and-neoplasia/wound-healing/acquire?ref=anki 

Flashcard 159: Fructose-1,6-bisphosphatase is regulated via negative feedback by _____ and AMP

Answer: fructose-2,6-bisphosphate

Extra:   Watch Gluconeogenesis [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-metabolism/videos/medical-biochemistry-metabolism-carbohydrates-gluconeogenesis?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch Reg PFK 1 FBPase 1 F 2, 6 BP Fed Fasting State [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-metabolism/videos/medical-biochemistry-metabolism-carbohydrates-gluconeogenesis?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/metabolism/glycolysis/acquire?ref=anki Other: 

Flashcard 160: Amine hormones are derivatives of the amino acid _____

Answer: tyrosine

Extra:   https://onlinemeded.org/spa/endocrine?ref=anki