Metabolism — Flashcards

Flashcard 1081: In total, the TCA cycle produces _____ GTP per acetyl-CoA

Answer: 1

Flashcard 1082: What enzyme converts T4 to T3 in the peripheral tissues?_____

Answer: 5' Deiodinase

Flashcard 1083: G6PD deficiency renders RBCs susceptible to _____ stress

Answer: oxidative

Flashcard 1084: Newly synthesized cGMP (from guanylyl cyclase activity) activates _____, which phosphorylates specific proteins responsible for physiologic actions

Answer: protein kinase G

Flashcard 1085: In the pancreatic beta cell, metabolism of glucose generates _____, which may cause closure of select K+ channels with consequent membrane depolarization

Answer: ATP

Flashcard 1086: Adenosine deaminase deficiency is one of the major causes of autosomal recessive _____

Answer: severe combined immunodeficiency (SCID)

Flashcard 1087: What is the molecular shorthand for **reduced glutathione**?

Answer: GSH (Glutathione-SH)

Extra: Reduced glutathione (GSH) contains a sulfhydryl group. Two molecules of GSH are oxidized to form **GSSG** (oxidized glutathione), which contains a disulfide bond.

Flashcard 1088: The more serious defects in galactose and fructose metabolism may lead to _____ depletion

Answer: phosphate (PO43-)

Flashcard 1089: 5-phosphoribosylamine is converted to _____, which may then be converted to AMP or GMP (purine synthesis)

Answer: IMP

Flashcard 1090: Electron transport inhibitors cause a _____ proton gradient and block of ATP synthesis

Answer: decreased