Glycolysis — Flashcards

Flashcard 1: phosphofructokinase-2/fructose bisphosphatase-2 (PFK-2/FBP-2)

Answer:

Extra: balances glycolysis and gluconeogenesisF-2,6-BP

Flashcard 2: Where does glycolysis take place?

Answer: cytoplasm

Flashcard 3: glycolysis

Answer: phosphofructokinase-1 (PFK-1)

Flashcard 4: What enzyme converts pyruvate to lactate?

Answer: lactate dehydrogenase (LDH)

Flashcard 5: glucokinase

Answer: first step of glycolysis and glycogen synthesis

Extra: tag glucose with phosphate so that it is trapped within the cellglucoseG6Pinsulinliver and β cells of pancreas

Flashcard 6: hexokinase

Answer: first step of glycolysis and glycogen synthesis

Extra: tag glucose with phosphate so that it is trapped within the cellglucoseG6PG6Pubiquitious

Flashcard 7: What steps of glycolysis produce ATP?

Answer: 1,3BPG to 3PG (via phosphoglycerate kinase); PEP to pyruvate (via pyruvate kinase)

Flashcard 8: What steps of glycolysis require ATP?

Answer: glucose to G6P (via hexokinase/glucokinase) F6P to F1,6BP (via phosphofructokinase-1)

Flashcard 9: Give the net chemical equation for glycolysis.

Answer: glucose + 2 Pi + 2 ADP + 2 NAD+ --> 2 pyruvate + 2 ATP + 2NADH + 2 H+ + 2 H2O

Flashcard 10: What is the effect of the different kinetic properties of hexokinase and glucokinase?

Answer: At low serum concentrations, hexokinase sequesters glucose in tissues. At high concentrations, excess glucose is processed and stored in liver.