Safe Prescribing — Flashcards

Flashcard 111: Which has a faster onset: _____

Answer: serotonin syndrome

Flashcard 112: Serotonin syndrome may present with diaphoresis, mydriasis, hypertension & tachycardia due to _____

Answer: autonomic dysfunction

Flashcard 113: What is the antidote to _____? Digoxin-specific antibody fragments (e.g. Digibind)

Answer: digoxin toxicity

Flashcard 114: _____ may be given to patients with suspected TCA overdose if the medication was taken in the past 1-2 hours

Answer: Activated charcoal

Flashcard 115: _____ poisoning may cause symptoms including: gastrointestinal symptoms, lethargy, confusion and vision changes such as Xanthopsia (yellow-tinted vision)

Answer: Digoxin

Flashcard 116: Patients with suspected digoxin toxicity should have an _____, serum digoxin, and U&Es

Answer: ECG

Flashcard 117: How can serotonin syndrome be differentiated from other drug-induced hyperthermias? _____

Answer: Serotonin syndrome causes neuromuscular excitability (hyperreflexia & myoclonus - particularly lower limbs)

Flashcard 118: Recreational drugs such as _____ and cocaine may cause serotonin syndrome

Answer: Ecstasy (MDMA)

Flashcard 119: Which condition is associated with ECG findings of a 'reverse tick' (sagging ST-segment depression)?\n\n_____

Answer: Digoxin toxicity

Extra: The characteristic ECG sign of digoxin is 'digitalis effect', seen as sagging ST-segment depression with a 'reverse tick' appearance. Toxicity can manifest as various arrhythmias, most commonly frequent PVCs, atrial tachycardia with AV block, or bidirectional VT.

Flashcard 120: The most important inhibitory effects of TCA toxicity are _____ inhibition and muscarinic ACh receptor inhibition

Answer: sodium channel