Rheumatology & Haematology — Flashcards

Flashcard 671: What is the main side effect of Doxorubicin (chemo)? _____

Answer: Irreversible congestive heart failure (dilated cardiomyopathy) and red urine

Extra: Doxorubicin causes Type I cardiotoxicity: Dose-dependent, oxidative damage-mediated, and irreversible. Compare with Trastuzumab (Type II), which is typically reversible.

Flashcard 672: What medications does ABVD chemotherapy include? _____ Bleomycin Vinblastine Dacarbazine

Answer: Doxorubicin (Adriamycin)

Flashcard 673: All patients with NHL should be tested for _____

Answer: HIV

Flashcard 674: Diagnostic criteria for MGUS in patients with serum paraprotein: 1. _____ 2. Monoclonal plasma cells in bone marrow <10% 3. Absence of symptoms (or organ involvement)

Answer: Serum paraprotein <30 g/L

Flashcard 675: _____ lymphoma is caused by uncontrolled proliferation of B-lymphocytes

Answer: Hodgkin's

Flashcard 676: What is the management of myeloma? _____

Answer: Autologous stem cell transplant

Flashcard 677: Multiple myeloma most commoly occurs in _____

Answer: the elderly (60-70)

Flashcard 678: The diagnostic criteria for myeloma can be remebered using the SLiM CRAB mnemonic. A individual with _____ AND any 1 of the following has myeloma: ≥ Sixty % plasma cells in marrow Light chain ratio ≥100 ≥ 1 focal lesion ≥5mm on MRI HyperCalcaemia Renal impairment Anaemia: Hb <100 g/L or 20g below normal Bone involvement (lytic lesion, osteoporosis, pathological fractures)

Answer: clonal bone marrow plasma cells ≥10%

Flashcard 679: Immunoglobulin light chains in the urine of a patient with myeloma are known as _____

Answer: Bence-Jones proteins

Flashcard 680: What are the 2 types of Bence-Jones proteins? _____

Answer: Lambda and Kappa