Rheumatology & Haematology — Flashcards

Flashcard 661: Which type of lymphoma has the greatest association with _____? Answer: Burkitt's lymphoma

Answer: EBV

Flashcard 662: _____ of patients diagnosed with NHL survive for >10 years following diagnosis

Answer: 2/3

Flashcard 663: Lymphoma is staged using the Ann Arbor staging system: Stage 1: _____ Stage 2: ≥2 lymph node regions on the same side of the diaphragm Stage 3: Lymph node regions on both sides of the diaphragm (may include extralymphatic involvement) Stage 4: Diffuse extralymphatic disease A - B symptoms absent B - With B symptoms E - Extra-nodal site involved X - Bulky disease

Answer: Single lymph node region or extralymphatic site

Flashcard 664: _____ of Waldenström macroglobulinemia or (rarely) lymphoma may lead to neurological symptoms (e.g. headache, vision changes, stroke-like)

Answer: Hyperviscosity syndrome

Flashcard 665: Lymphoma is staged using the _____ staging system

Answer: Ann Arbor

Flashcard 666: _____ presenting with unexplained lymphadenopathy should be considered for a 2-week-wait referral for lymphoma

Answer: Adults

Flashcard 667: The most common site of _____ involvement in lymphoma is the Gastrointestinal (GI) tract (specifically the stomach)

Answer: extranodal

Extra: Primary sites of lymphoma are the lymph nodes. When it occurs outside the nodes (extranodal), the GI tract is #1, followed by the skin. The spleen and liver are common sites of systemic involvement (stage IV disease) but not the most common extranodal sites overall.

Flashcard 668: Osteolytic lesions caused by myeloma typically occur in the _____

Answer: skull & vertebrae

Flashcard 669: Myeloma may cause hypercalcaemia due to increased _____ activity which results in osteolytic lesions

Answer: osteoclast

Flashcard 670: Myeloma is a _____ disease - there is no cure

Answer: relapsing / remitting