Rheumatology & Haematology — Flashcards

Flashcard 661: NHL may arise from which cell types? _____, T lymphocyte, NK cell

Answer: B lymphocyte

Flashcard 662: A typical FBC in a patient with NHL will show _____, thrombocytopenia, neutropenia, lymphocytosis

Answer: anaemia

Flashcard 663: What is the main side effect of Vincristine/Vinblastine (chemo)? _____

Answer: Peripheral neuropathy (vincristine) & Myelosupression (vinblastine)

Flashcard 664: What is the main side effect of Doxorubicin (chemo)? _____

Answer: Irreversible congestive heart failure (dilated cardiomyopathy) and red urine

Extra: Doxorubicin causes Type I cardiotoxicity: Dose-dependent, oxidative damage-mediated, and irreversible. Compare with Trastuzumab (Type II), which is typically reversible.

Flashcard 665: Hodgkin's lymphoma generally has a _____ prognosis

Answer: good

Flashcard 666: Diagnostic criteria for smouldering myeloma: 1. _____ 2. Absence of symptoms (and organ involvement)

Answer: Serum paraprotein ≥30 g/L (and/or clonal marrow plasma cells 10-60%)

Flashcard 667: Anaemia and thrombocytopenia associated with myeloma is caused by _____

Answer: overcrowding of the bone marrow

Flashcard 668: What is the management of myeloma? _____

Answer: Autologous stem cell transplant

Flashcard 669: Bone pain caused by myeloma may be treated with _____ or radiotherapy

Answer: analgesics

Extra: Note: NSAIDs should be avoided in Multiple Myeloma patients due to the high risk of renal impairment (cast nephropathy).

Flashcard 670: Risk factors for Hodgkin's lymphoma include _____, immunosupression and 1st degree relative affected

Answer: EBV