Rheumatology & Haematology — Flashcards

Flashcard 651: All patients with NHL should be tested for _____

Answer: HIV

Flashcard 652: What are the diagnostic investigations for NHL? _____, Immunophenotyping

Answer: LN excision biopsy

Flashcard 653: What is the main side effect of Doxorubicin (chemo)? _____

Answer: Irreversible congestive heart failure (dilated cardiomyopathy) and red urine

Extra: Doxorubicin causes Type I cardiotoxicity: Dose-dependent, oxidative damage-mediated, and irreversible. Compare with Trastuzumab (Type II), which is typically reversible.

Flashcard 654: _____-grade NHL usually has a better prognosis but is less curable

Answer: Low

Flashcard 655: What is the 1st line managment of Hodgkin's lymphoma? _____

Answer: Chemotherapy (ABVD)

Flashcard 656: There are more than _____ types of Non-Hodgkin's lymphoma which can be broadly categorised into low-grade and high-grade

Answer: 60

Flashcard 657: What is the main side effect of _____? Acute pancreatitis

Answer: L-asparaginase

Extra: L-asparaginase depletes serum asparagine, inhibiting protein synthesis. Key side effects: 1. **Acute Pancreatitis** (classic Boards association) 2. **Thrombosis** (due to depletion of Antithrombin III, Protein C, and S) 3. **Hypersensitivity/Anaphylaxis** 4. **Hyperglycemia** (decreased insulin synthesis)

Flashcard 658: _____ lymphoma is associated with malaria infection

Answer: Burkitt's

Flashcard 659: _____ lymphoma usually causes jaw lymphadenopathy

Answer: Burkitt's

Flashcard 660: What is the pharmacological managment of high-grade NHL at risk of CNS involvement? _____ and Intrathecal methotrexate or cytarabine

Answer: Chemotherapy - R-CHOP