Rheumatology & Haematology — Flashcards

Flashcard 651: A typical FBC in a patient with NHL will show _____, thrombocytopenia, neutropenia, lymphocytosis

Answer: anaemia

Flashcard 652: What is the main side effect of _____? Acute pancreatitis

Answer: L-asparaginase

Extra: L-asparaginase depletes serum asparagine, inhibiting protein synthesis. Key side effects: 1. **Acute Pancreatitis** (classic Boards association) 2. **Thrombosis** (due to depletion of Antithrombin III, Protein C, and S) 3. **Hypersensitivity/Anaphylaxis** 4. **Hyperglycemia** (decreased insulin synthesis)

Flashcard 653: Hodgkin's lymphoma generally has a _____ prognosis

Answer: good

Flashcard 654: _____ of patients diagnosed with NHL survive for >10 years following diagnosis

Answer: 2/3

Flashcard 655: What is the pharmacological managment of high-grade NHL? _____

Answer: Chemotherapy - R-CHOP

Flashcard 656: There are more than _____ types of Non-Hodgkin's lymphoma which can be broadly categorised into low-grade and high-grade

Answer: 60

Flashcard 657: Usually lymphomas arising from _____ are low-grade and lymphomas arising from lymphoblasts are high-grade

Answer: mature lymphocytes

Flashcard 658: _____ of Waldenström macroglobulinemia or (rarely) lymphoma may lead to neurological symptoms (e.g. headache, vision changes, stroke-like)

Answer: Hyperviscosity syndrome

Flashcard 659: What are the diagnostic investigations for NHL? _____, Immunophenotyping

Answer: LN excision biopsy

Flashcard 660: _____ lymphoma is associated with translocation of the MYC oncogene

Answer: Burkitt