Rheumatology & Haematology — Flashcards

Flashcard 461: SLE malar rash ("butterfly rash") spares the _____

Answer: nasolabial folds

Flashcard 462: SLE patients taking hydroxychloroquine should be monitored for _____

Answer: retinal toxicity (chloroquine maculopathy)

Flashcard 463: What protein deficiency is associated with SLE?

Answer:

Flashcard 464: Which antibody correlates with disease activity & lupus nephritis activity in SLE? _____

Answer: anti-dsDNA

Flashcard 465: What is the immunosuppressive management of SLE? Long-term: _____ Acute exacerbations/flares: Glucocorticoids Active glomerulonephritis/severe flares: IV cyclophosphamide + glucocorticoid

Answer: Hydroxychloroquine

Flashcard 466: Systemic lupus erythematosus (SLE) may affect the brain, causing _____ or psychosis

Answer: seizures

Flashcard 467: What is the symptomatic management of SLE? _____

Answer: NSAIDs

Flashcard 468: The characteristics of systemic lupus erythematosus (SLE) may be remembered with the mnemonic _____

Answer: RASH OR PAIN

Extra: The mnemonic **RASH OR PAIN** for SLE criteria: - **R**ash (Malar) - **A**rthritis - **S**erositis - **H**ematologic disorders (anemia, leukopenia) - **O**ral ulcers - **R**enal disease - **P**hotosensitivity - **A**ntinuclear antibody (ANA) - **I**mmunologic markers (Anti-dsDNA, Anti-Sm, etc.) - **N**eurological disorders (seizures, psychosis)

Flashcard 469: SLE clasically presents with _____, malar rash ("butterfly rash"), & constitutional symptoms

Answer: arthritis

Flashcard 470: Which antibody is sensitive for drug-induced lupus? _____

Answer: anti-histone