Rheumatology & Haematology — Flashcards

Flashcard 471: _____ is an idiopathic, multisystem autoimmune disease characterised by +ve ANA, arthralgias, & constituitional symptoms

Answer: Systemic lupus erythematosus (SLE)

Flashcard 472: SLE causes of death: 1) _____ 2) infection (cytopaenias & immunosuppressive therapy) 3) renal disease 4) neurological (seizures)

Answer: cardiovascular disease

Flashcard 473: SLE patients have a life expectancy approx. _____ years shorter than the general population.

Answer: 15-25

Flashcard 474: How are infections prevented in SLE? _____

Answer: Vaccinate! Offer influenza & pneumococcal vaccinations

Flashcard 475: Systemic lupus erythematosus (SLE) may affect the brain, causing _____ or psychosis

Answer: seizures

Flashcard 476: SLE follows a _____ course progression

Answer: relapsing-remitting

Flashcard 477: The characteristics of _____ may be remembered with the mnemonic "RASH OR PAIN": Rash (malar or discoid) Arthritis (usually involving ≥ 2 joints) Serositis (pleuritis and pericarditis) Hematologic disorders (e.g. cytopenias) Oral or nasopharyngeal ulcers (usually painless) Renal disease Photosensitivity Antinuclear antibodies Immunologic disorder (anti-dsDNA, anti-Smith, antiphospholipid) Neurologic disorder (seizures, psychosis)

Answer: systemic lupus erythematosus (SLE)

Flashcard 478: The characteristics of systemic lupus erythematosus (SLE) may be remembered with the mnemonic _____

Answer: RASH OR PAIN

Extra: The mnemonic **RASH OR PAIN** for SLE criteria: - **R**ash (Malar) - **A**rthritis - **S**erositis - **H**ematologic disorders (anemia, leukopenia) - **O**ral ulcers - **R**enal disease - **P**hotosensitivity - **A**ntinuclear antibody (ANA) - **I**mmunologic markers (Anti-dsDNA, Anti-Sm, etc.) - **N**eurological disorders (seizures, psychosis)

Flashcard 479: SLE malar rash ("butterfly rash") spares the _____

Answer: nasolabial folds

Flashcard 480: SLE has accelerated _____ that is the most common cause of death

Answer: atherosclerosis