Rheumatology & Haematology — Flashcards

What is the effect of polycythemia on blood viscosity? _____

↑ Hb ↑ Haematocrit with ↓ EPO normal O2 sats = _____ ↑ Hb ↑ Haematocrit with ↑ EPO & ↓ O2 sats = secondary polycythaemia

Chronic myeloid leukaemia is overexpression of the _____ lineage, particularly granulocytes (neutrophils, basophils, eosinophils)

Chronic phase of CML can be asymptomatic, when symptomatic it presents with _____

How does _____ affect cells? ↑ Erythrocytosis with or without ↑ granulocytosis or thrombocytosis

Hint: myeloproliferative disorder

What is the most common cause of secondary polycythaemia? _____

Chronic myeloid leukaemia is a _____ disorder

What is the first-line management of chronic myeloid leukaemia that is used regardless of the phase? _____

Which form of polycythaemia is associated with lung disease (e.g. COPD / obstructive sleep apnea), congenital heart disease, high altitude, or low birth weight? _____

What are the initial investigations for chronic myeloid leukaemia? _____

Hint: 2