Rheumatology & Haematology — Flashcards

What is the likely diagnosis in a patient with night sweats, weight loss, and splenomegaly? Laboratory exam reveals leucocytosis with increased levels of basophils and myelocytes. _____

Hint: diagnosis?

_____ is the terminal phase in CML where it progresses to an acute leukaemia

Polycythaemia vera has a mutation of the _____ gene that ↑ tyrosine kinase activity causing EPO-independent erythrocytosis

What are the examination finding(s) of chronic myeloid leukaemia? _____

What phase do >90% of patients present in with chronic myeloid leukaemia? _____

How does _____ affect cells? Initial hyperproliferative phase (esp megakaryocytes) → followed by pancytopenia

Hint: myeloproliferative disorder

What are the confirmatory investigations for polycythaemia vera? _____

Hint: 2

Chronic myeloid leukaemia is often diagnosed _____ on a FBC

Chronic myeloid leukemia is usually insidious in onset and seen in _____

Hint: demographic

How does _____ affect cells? ↑ thrombocytes

Hint: myeloproliferative disorder