Rheumatology & Haematology — Flashcards

Flashcard 431: What is the first-line management of chronic myeloid leukaemia that is used regardless of the phase? _____

Answer: Tyrosine kinase inhibitors (e.g. imatinib)

Flashcard 432: How does _____ affect cells? ↑ Erythrocytosis with or without ↑ granulocytosis or thrombocytosis

Answer: polycythaemia vera

Flashcard 433: ↑ Hb ↑ Haematocrit with ↓ EPO normal O2 sats = _____ ↑ Hb ↑ Haematocrit with ↑ EPO & ↓ O2 sats = secondary polycythaemia

Answer: Primary polycythaemia (polycythaemia vera)

Flashcard 434: _____ are a group of disorders characterised by abnormal proliferation of normally developed stem cells of the myeloid cell lineage

Answer: Myeloproliferative disorders

Flashcard 435: How does _____ affect cells? ↑ granulocytes (neutrophils, eosinophils, & basophils)

Answer: chronic myeloid leukaemia

Flashcard 436: Polycythaemia vera is a form of _____ polycythemia

Answer: primary

Flashcard 437: A rapidly enlarging _____ in chronic myeloid leukemia (CML) suggests progression from accelerated phase to blast crisis

Answer: spleen

Flashcard 438: The t(9;22) translocation (BCR-ABL) is also known as the _____ chromosome most commonly seen in chronic myeloid leukaemia (CML)

Answer: Philadelphia

Flashcard 439: What is the effect of polycythemia on blood viscosity? _____

Answer: Increased

Flashcard 440: Secondary polycythemia (due to hypoxemia) is characterized by _____ SaO2 percentage.

Answer: decreased

Extra: Other causes of secondary polycythemia (like EPO-secreting tumors) may have normal SaO2 but elevated EPO.