Rheumatology & Haematology — Flashcards

Delayed transfusion haemolytic transfusion reaction has +ve _____ test

How does myelofibrosis lead to massive splenomegaly (pathophysiology)? _____

Which blood transfusion reaction can be caused by ABO incompatability? _____

What is the definitive management of myelofibrosis? _____

What is the likely diagnosis in a patient that develops wheezing, urticaria, respiratory distress, and hypotension minutes after receiving a RBC transfusion? _____

Hint: diagnosis?

What are the examination finding(s) of myelofibrosis? _____

Which blood transfusion reaction is caused by antibodies against minor antigens (e.g. Duffy, Kell, or Rh systems) leading to extravascular haemolysis? _____

What physical exam finding can distinguish myelofibrosis from aplastic anemia? _____

What are the initial investigations for myelofibrosis? _____

Hint: 2

Direct antiglobluin (Coombs) test _____ = febrile non-haemolytic transfusion reaction Direct antiglobluin (Coombs) test +ve = acute haemolytic transfusion reaction