Rheumatology & Haematology — Flashcards

Flashcard 291: Acute myeloid leukemia progresses _____ within days to weeks

Answer: rapidly

Flashcard 292: Leukaemic cells can infiltrate the skin resulting in leukaemia cutis particularly in acute _____ leukaemia

Answer: myeloid

Flashcard 293: Does acute myeloid leukaemia typically present with lymphadenopathy and hepatosplenomegaly? _____

Answer: No (rare)

Flashcard 294: The confirmatory investigation for acute myeloid leukaemia (AML) is _____.

Answer: Bone marrow aspiration & biopsy

Extra: AML is suggested by Auer rods on peripheral smear. Confirmed by BM biopsy showing ≥ 20% myeloblasts. Special stains: Myeloperoxidase (MPO) positive.

Flashcard 295: Acute lymphoblastic leukemia can cause _____ because of suppression of thrombocytopoiesis

Answer: bleeding/bruising

Flashcard 296: What are the initial investigations for acute myeloid leukaemia? _____

Answer: FBC (very urgent within 48 hours) & peripheral blood smear

Flashcard 297: Acute lymphoblastic leukemia progresses _____ within days to weeks

Answer: rapidly

Flashcard 298: Acute myeloid leukaemia is a malignant proliferation of _____ cells

Answer: myeloid progenitor

Flashcard 299: Acute myeloid leukaemia is classified using the _____ classification system to predict prognosis and guide management decisions.

Answer: WHO (2022)

Extra: The WHO (2022) classification and the International Consensus Classification (ICC) are the current standards. Most AML subtypes still require ≥20% blasts in the blood or bone marrow, though some genetic-defined AMLs (like APL) can be diagnosed with lower blast counts.

Flashcard 300: Acute myeloid leukemia can cause _____ because of suppression of immune cells

Answer: infections