Rheumatology & Haematology — Flashcards

_____ is thrombosis, haemorrhage, & organ dysfunction caused by systemic activation of blood coagulation causing fibrin clots, platelet consumption & exhaustion of clotting factors

Disseminated intravascular coagulation (DIC) presents with: _____ platelet count (FBC) ↑ aPTT (coagulation studies) ↑ PT ↓ fibrinogen ↑ D-dimer

Hint: ↑/↓

What are the initial investigations for suspected disseminated intravascular coagulation (DIC)? _____

Hint: 2

Disseminated intravascular coagulation (DIC) presents with _____ & thrombosis

How do platelet levels change post-splenectomy? _____

How do lymphocyte levels change post-splenectomy? _____

What are the causes of disseminated intravascular coagulation (DIC)? 1. _____ 2. Trauma (inc. burns) 3. Obstetric conditions (e.g. amniotic fluid embolism) 4. Malignancy (e.g. APL)

What is the most common cause of disseminated intravascular coagulation (DIC)? _____

In DIC where thrombosis predominates, consider management with _____

Disseminated intravascular coagulation (DIC) may occur secondary to obstetric complications due to activation of the coagulation cascade by _____ in the amniotic fluid