Rheumatology & Haematology — Flashcards

The sickle cell allele / HbS provides protection against _____, which likely explains the high prevalence in Africans

What is the confirmatory diagnosis of sickle cell disease? _____

Sickle cell disease can cause _____ due to vaso-occlusion of cerebral vessels

What is the likely diagnosis in an African American infant that presents with symmetric swelling/tenderness of the bilateral hands and feet? _____

Hint: diagnosis?

Vaso-occlusive crisis presents with _____ to an affected area (e.g. limbs, chest, back) for several hours up to ~7 days

Vaso-occlusive crisis is _____ of tissue secondary to microvascular occlusion from sickled RBCs

_____ is the most common cause of osteomyelitis in patients with sickle cell disease

Sickle cell trait presents _____, unless in severe conditions

_____ commonly causes aplastic crisis in patients with sickle cell disease because of temporary suppression of erythropoiesis

Acute haemolytic crisis in sickle cell disease may require _____

Hint: management