Rheumatology & Haematology — Flashcards

The sickle cell allele / HbS provides protection against _____, which likely explains the high prevalence in Africans

Sickle cell disease can be complicated with _____ from encapsulated organisms causing sepsis, pneumonia, & meningitis

Sickle cell disease often has persistent, mild _____cytic anaemia on FBC

Sickle cell disease and fever is managed with _____

Hint: next step

Spot diagnosis = _____

Hint:

Acute chest syndrome in patients with sickle cell disease is often precipitated by _____

Vaso-occlusive crisis presents with _____ to an affected area (e.g. limbs, chest, back) for several hours up to ~7 days

In sickle cell disease, the spleen becomes dysfunctional in _____ ("splenic fatigue")

Hint: demographic

What are the major causes of acute severe anaemia in sickle cell disease? _____: ↓ reticulocyte count + no splenomegaly Splenic sequestration (Vaso-occlusion): ↑ reticulocyte count + splenomegaly

Vaso-occlusive crisis is also known as _____ crisis