Rheumatology & Haematology — Flashcards

Vaso-occlusive crisis is _____ of tissue secondary to microvascular occlusion from sickled RBCs

Aplastic crisis will present with a _____ reticulocyte count

Sickle cell disease can cause _____ that involves splenic vaso-occlusion and pooling of large amounts of blood in the spleen

What is the 1st-line management for sickle cell disease if clinically indicated? _____

_____ is a possible feature of sickle cell disease that involves acute & reversible reticulocytopaenia

What RBC pathology is characterized by the following Hb electrophoresis findings: 55% HbA, 43% HbS, and 2% HbA2 _____

Sickle cell disease can be complicated with _____ from encapsulated organisms causing sepsis, pneumonia, & meningitis

What is the most common acute complication/event in sickle cell disease? _____

What are the major causes of acute severe anaemia in sickle cell disease? _____: ↓ reticulocyte count + no splenomegaly Splenic sequestration (Vaso-occlusion): ↑ reticulocyte count + splenomegaly

The sickle cell allele / HbS provides protection against _____, which likely explains the high prevalence in Africans