Rheumatology & Haematology — Flashcards
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What RBC pathology is characterized by the following Hb electrophoresis findings: 55% HbA, 43% HbS, and 2% HbA2 _____
Spot diagnosis = _____
Hint:
Acute haemolytic crisis in sickle cell disease may require _____
Hint: management
_____ is typically the earliest manifestation of sickle cell disease in infants <5yrs old
What is the initial general management for vaso-occlusive crisis/events? _____
Sickle cell disease can cause _____ due to vaso-occlusion of cerebral vessels
hydroxycarbamide(hydroxyurea) is useful in the treatment of sickle cell disease because it increases ↑ levels of _____ (typically >15%)
Sickle cell disease can be complicated with _____ from encapsulated organisms causing sepsis, pneumonia, & meningitis
Vaso-occlusive events can affect multiple organs: _____= bones in hand & feet (especially in <5yrs) Priapism= penis Stroke= cerebral vessels Acute chest syndrome = lungs Avascular necrosis= bones (particularly femoral head)
Sickle cell anaemia is often _____ in newborns.
Hint: clinical presentation
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