Rheumatology & Haematology — Flashcards

_____ is considered in severe vaso-occlusive crisis/events, e.g. acute chest syndrome or stroke

Hint: Management

What is the initial general management for vaso-occlusive crisis/events? _____

What is the confirmatory diagnosis of sickle cell disease? _____

Acute haemolytic crisis in sickle cell disease may require _____

Hint: management

Spot diagnosis = _____

Hint:

In sickle cell disease, the spleen becomes dysfunctional in _____ ("splenic fatigue")

Hint: demographic

What is the likely diagnosis in an African American infant that presents with symmetric swelling/tenderness of the bilateral hands and feet? _____

Hint: diagnosis?

What is the 1st-line management for sickle cell disease if clinically indicated? _____

What are the major causes of acute severe anaemia in sickle cell disease? _____: ↓ reticulocyte count + no splenomegaly Splenic sequestration (Vaso-occlusion): ↑ reticulocyte count + splenomegaly

_____ is typically the earliest manifestation of sickle cell disease in infants <5yrs old