Rheumatology & Haematology — Flashcards

~80% of cases are haemophilia _____ caused by genetic factor VIII deficiency

In haemophilia A, mixing normal plasma with the patient's plasma (mixing study) _____ correct the aPTT

Hint: does/doesn't

Thalassaemia genes are inherited in an _____ fashion.

Alpha thalassaemia major (haemoglobin Bart's disease) often results in _____ in utero

Which coagulation disorder presents with recurrent haemarthroses, spontaneous / easy bruising, and bleeding after surgery? _____

What is the most accurate investigation for haemophilia? _____

What is the general management for thalassaemia major? _____

Hint: 2

Thalassaemia is associated with a(n) _____ red cell distribution width (RDW)

What is the general management for thalassaemia intermedia or haemoglobin H disease (- -/-α)? _____

Petechial bleeding is a common sign of _____ disorders

Hint: coagulation/platelet