Gastroenterology & Hepatology — Flashcards

Flashcard 471: In a patient with autoimmune hepatitis, be wary of _____ co-morbidity as it can cause malabsorption of immunosuppressive drugs

Answer: coeliac disease

Flashcard 472: Type _____ autoimmune hepatitis is the most common (70-80%)

Answer: 1

Flashcard 473: What is the mainstay investigation to diagnose hepatitis C? _____ → HCV RNA (if anti-HCV antibody test is +ve)

Answer: Anti-HCV antibodies

Flashcard 474: Type _____ autoimmune hepatitis typically affects women in their 40s/50s but can affect all ages

Answer: 1

Extra: Type 1 Autoimmune Hepatitis is associated with: - Positive **ANA** (Anti-Nuclear Antibody) - Positive **ASMA** (Anti-Smooth Muscle Antibody) - Elevated IgG levels

Flashcard 475: Type _____ autoimmune hepatitis typically affects younger patients but can affect all ages

Answer: 2

Flashcard 476: Autoimmune hepatitis is associated with other autoimmune diseases, most commonly _____

Answer: autoimmune thyroid disease

Flashcard 477: Type _____ autoimmune hepatitis is the most severe

Answer: 2

Flashcard 478: What is the mainstay management of autoimmune hepatitis? _____

Answer: Corticosteroids (e.g., prednisolone) +/- Azathioprine

Extra: The goal of treatment is to induce and maintain remission. Prednisolone is used for induction, while Azathioprine is often added as a steroid-sparing agent for maintenance.

Flashcard 479: Type _____ autoimmune hepatitis antibodies are anti-liver kidney microsomal-1 (LKM-1) ± anti-liver cytosolic-1 (LC-1)

Answer: 2

Flashcard 480: Autoimmune hepatitis can present with _____ in ~40% of patients and ~30% have cirrhosis at the time of presentation

Answer: jaundice