Endocrinology & Diabetes — Flashcards

What investigation is used to help differentiate/localise the pathology in Cushing's disease from ectopic ACTH? \n_____

High dose dexamethasone suppression test:\n_____ cortisol + Low/Suppressed ACTH = Adrenal tumor (Adenoma/Carcinoma)

What is the management of Cushing's disease if trans-sphenoidal surgery / radiation fails? _____

One clinical feature seen in women with Cushing's syndrome is _____ as a result of increased androgen levels

High dose dexamethasone suppression test: _____ cortisol ↑ ACTH = Ectopic ACTH (small cell lung cancer)

Hint: ↓/↑

One clinical feature of Cushing syndrome is _____, which is a result of decreased osteoblast activity

One clinical feature of Cushing syndrome is muscle weakness with _____ extremities

Hint: appearance

High dose dexamethasone suppression test: ↓ cortisol = _____

Clinical features of _____ include moon facies, buffalo hump, and truncal obesity due to increased lipogenesis/fat storage, secondary to excess insulin levels (compensatory).

Pseudo-cushing's can mimic Cushing's syndrome and is usually due to _____ or severe depression